Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-237-5 | CAS number: 2680-03-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
The oral LD50 was >215 and <464 mg/kg bw, the inhalation LC50 (after 1 h exposure) was >3.16 mg/L and the dermal LD50 was 500-2000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
Additional information
Oral toxicity
In a study comparable to OECD guideline 401, Sprague-Dawley rats (males and females, 5 per sex per dose) were administered N,N-dimethylacrylamide at dose levels of 46.4, 100, 215 and 464 mg/kg bw by single dose (in distilled water by gavage (USEPA, 1992)). All animals of the high dose group (464 mg/kg bw) were found dead 24 hours after dosing. No deaths occurred in the other dose groups. At 46.4, 100 and 215 mg/kg bw, all animals appeared slightly depressed at four hours. After 24 hours, all animals appeared normal. At 464 mg/kg bw, slight depression was observed in all animals immediately post dosing. Hunching, depression, and ataxia or ptosis at one hour preceded death at 24 hours in all animals. No observable gross pathology was noted at death or termination. The LD50 was >215 and <464 mg/kg bw.
Inhalation toxicity
In an inhalation hazard test according to US OSHA Regulation 29 CFR 1910.1200, Sprague-Dawley rats (5/sex) were exposed to N,N-dimethylacrylamide as vapour for 1 hour at a measured concentration of 3.16 mg/L (776 ppm, the highest achievable vapour concentration at 35 ºC) followed by a 14-day observation period (USEPA, 1998). No mortality occurred during the study. Fur coated with feces/urine was observed in all animals at 1 hour after exposure. For the remainder of the study, all animals appeared normal. Body weight gain of surviving animals was unaffected by the administration of the test substance. The gross necropsy conducted on each animal at termination of the study revealed no observable abnormalities, except for red lungs in three females. The LC50 was >3.16 mg/L.
Dermal toxicity
In a thirteen-week dermal toxicity study comparable to OECD guideline 411, 2/20 female rats exposed to 500 mg/kg bw N,N-dimethylacrylamide died within the first week of dosing (USEPA, 1996). Based on this the LD50 can be assumed to be 500 -2000 mg/kg bw.
Justification for classification or non-classification
Based on the available data, N,N-dimethylacrylamide has to be classified for acute oral and dermal toxicity. According to Directive 67/548/EEC, classification with Xn, R21/22 is warranted. According to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008, the classification is H301, Cat. 3 and H311, Cat. 3.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)