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EC number: 202-445-8 | CAS number: 95-73-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
- GLP compliance:
- not specified
- Type of study:
- other: Landsteiner test, modified
Test material
- Reference substance name:
- Benzene, 2,4-dichloro-1-methyl-
- IUPAC Name:
- Benzene, 2,4-dichloro-1-methyl-
- Reference substance name:
- 2,4-dichlorotoluene
- EC Number:
- 202-445-8
- EC Name:
- 2,4-dichlorotoluene
- Cas Number:
- 95-73-8
- Molecular formula:
- C7H6Cl2
- IUPAC Name:
- 2,4-dichloro-1-methylbenzene
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- guinea pig
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- other: sesamum oil
- Concentration / amount:
- 0,1 %
Challengeopen allclose all
- Route:
- intradermal
- Vehicle:
- other: sesamum oil
- Concentration / amount:
- 0,1 %
- No. of animals per dose:
- 8 animals per dose
- Details on study design:
- 8 Guinea pigs were used for the test. The guinea pigs were sheared in shoulder and back areas.
Induction period:
A solution of 0.1 % 2,4-dichlorotoluene (dissolved in sesame oil) was injected intradermally into the shoulder and back areas of each guinea pig.
First injection: 0.05 ml/animal, all other injections 0.1 ml/animal.
Within a period of 3 weeks the substance was injected 3 times per week (in total 9 injections).
Control groups: 4 guinea pigs were used for negative control (sesame oil), 4 other guinea pigs were used for positive control (2,4-dinitrochlorobenzene) - Challenge controls:
- Following initial exposure to a test substance (induction period) the animals are subjected 10 days after the last induction exposure to a challenge exposure (challenge period) to the test substance in order to establish if a hypersensitive state has been induced. Doses of 0.05 ml/animal of the 0.1% solution were injected intradermally.
Readings were made 24 and 48 hours later.
2,4-Dichlorotoluene showed no sensitizing effect. - Positive control substance(s):
- yes
- Remarks:
- 2,4-dinitrochlorobenzene
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- 2,4-Dichlorotoluene showed no sensitizing effect.
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