Registration Dossier
Registration Dossier
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EC number: 256-350-1 | CAS number: 48076-38-6
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
All substances in the category are readily biodegradable (but failing the 10-day window). Further the water solubility of the test substance is very low (<20 µg/L at 20°C). Hence, this is not a required endpoint in accordance with column 2 Annex VII section 9.2.2.1 of Regulation (EC) No 1907/2006 (REACH).
In general, acrylate esters are stable at neutral and acidic pH. Under alkaline conditions at pH 9 or 11 significant hydrolysis is observed with a trend to a decrease of the hydrolysis rate with increasing chain length and branching. This is partly due to increased steric hindrance and partly due to decreasing alkoxide stability during ester cleavage. The most common base hydrolysis mechanism BAC2 involves cleavage of the carbonyl-alkoxide oxygen bond to form the free alkoxide. The alkoxide formed is more basic the longer the chain length is and as stronger bases make poorer leaving groups, wherefore the rate of cleavage and hydrolysis is also slower. For details see "Advanced Organic Chemistry", Sixth Edition, Wiley, 2007 p 1400 ff.
Under normal environmental conditions, abiotic degradation by hydrolysis is not expected to play an important role in the degradation of long-chain acrylate esters in the environment.
Key value for chemical safety assessment
Additional information
This is not a required endpoint in accordance with column 2 Annex VII section 9.2.2.1 of Regulation (EC) No 1907/2006 (REACH), as all substances in the category are readily biodegradable (but failing the 10-day window) and the water solubility of the test substance is very low (<20 µg/L at 20°C).
Supporting information is available for dodecyl acrylate. For the assessment of dodedecyl acrylate (Q)SAR results were used for assessment of hydrolysis.The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment. Further experimental studies are not provided.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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