Registration Dossier
Registration Dossier
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EC number: 203-013-1 | CAS number: 102-20-5
Endpoint summary
Administrative data
Description of key information
Hydrolysis:
HYDROWIN v2.00 program of Estimation Programs Interface prediction model was used to predict the hydrolysis half-life of test chemical. The estimated half-life of test chemical was determined to be 321.131 days and 32.113 days at pH 7.0 and 8.0 (at 25°C) respectively, indicating that it is not hydrolysable.
Additional information
Hydrolysis:
Various predicted data of the test chemical and weight of evidence studies for its structurally and functionally similar read across substance have been were reviewed for the hydrolysis end point which are summarized as below:
HYDROWIN v2.00 program of Estimation Programs Interface prediction model was used to predict the hydrolysis half-life of test chemical. The estimated half-life of test chemical was determined to be 321.131 days and 32.113 days at pH 7.0 and 8.0 (at 25°C) respectively, indicating that it is not hydrolysable.
Above study further supported by the second study from authoritative database. The half-life of the test chemical was determined using an estimated pseudo-first order hydrolysis rate constant of 0.00000021/sec at a temperature of 25°C and pH 7.0. The half-life of test chemical was determined to be 38 days at pH 7. Based on the half-life values, it is concluded that the chemical test chemical is not hydrolysable.
Similar study from authoritative database, the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.038L/mol-sec with a corresponding half-lives of 6 years and 211 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
Based on the above all studies from various sources, it is concluded that the test chemical is non hydrolysable.
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