3,7-dimethyloct-6-en-1-yn-3-ol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

10/02/1988 - 24/02/1988

Reliability:

2 (reliable with restrictions)

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

No remarks

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

3,7-dimethyloct-6-en-1-yn-3-ol

EC Number:

249-482-6

EC Name:

3,7-dimethyloct-6-en-1-yn-3-ol

Cas Number:

29171-20-8

Molecular formula:

C10H16O

IUPAC Name:

3,7-dimethyloct-6-en-1-yn-3-ol

Details on test material:

- Name of test material (as cited in study report): Dehydrolinalool
- Physical state: liquid, slightly yellowish
- Expiration date of the lot/batch: at least for the time range of the current test
- Storage condition of test material: room temperature

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Dr. K. Thomae GmbH, 7950 Biberach
- Age at study initiation: 8-9 weeks
- Weight at study initiation: males 280 g, females 216 g
- Housing: 3 animals in a cage type D III (Becker & Co.)
- Diet (e.g. ad libitum): ad libitum in the exposition free period
- Water (e.g. ad libitum): ad libitum in the exposition free period
- Acclimation period: at least 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24 °C
- Humidity (%): 30-70 %
- Photoperiod (hrs dark / hrs light): 12

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

Exposure atmosphere was generated using a test substance filled flask which was held at 20°C. Test substance was weighed in the flask. An airflow with 200 L/h was conveyed through the flask and the generated test atmosphere was conveyed to the animals held in glass animal restrainers. After 30 minutes, a new flask was used. The exposure was 7h.

Duration of exposure:

7 h

Concentrations:

The amount of test substance used was determined by weighing. The nominal concentration was calculated using the amount of substance used and the airflow. The nominal concentration was 1 mg/L.

No. of animals per sex per dose:

3

Control animals:

not specified

Details on study design:

Animals were examined for clinical signs up to 14 days.

Statistics:

No remarks

Results and discussion

Preliminary study:

No remarks

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 1 mg/L air (nominal)

Remarks on result:

other: highest concentration testeed

Mortality:

All animals survived.

Clinical signs:

other: During exposure clinical signs consisted of increased breathing rate and snout wiping.

Body weight:

No remarks

Gross pathology:

No findings were seen at necropsy.

Other findings:

Not relevant

Any other information on results incl. tables

Not relevant