Registration Dossier
Registration Dossier
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EC number: 205-527-1 | CAS number: 142-19-8
Endpoint summary
Administrative data
Description of key information
Additional information
Valid acute toxicity tests with the test substance are available for three freshwater species from three trophic levels.
The studies show that fish is the most sensitive species with a LC50 = 0.0505 mg/L (flow-through, aquaria covered with glass lids).
In a static daphnia study over 48h conducted with closed bottles an EC50 of 0.89 mg/L was observed. A valid algal growth inhibition study over 72-hour resulted in an ErC50 of 1.94 mg/L and an ErC10 of 1.29 mg/L. No test on toxicity to microorganisms is available, but the toxicity control in the available study on ready biodegradability at a nominal concentration of 100 mg/L did not inhibit the microbial activity. On this basis, a NOEC of >= 100 mg/L was derived for the inhibition of microorganisms.
A chronic fish test is available for the structurally related read-across substance ACHP. In a flow-through test over in total 33 days an EC10 of 64 µg/L was observed. Considering the different molecular weight an EC10 of 55.5 µg/L can be used for the risk assessment.
As the results of the acute tests show, that fish are clearly the most sensitive species, the endpoint long-term toxicity to aquatic invertebrates was covered with a QSAR prediciton from ECOSAR 2.2. resulting in a ChV of 0.528 mg/L which is supporting that invertebrates are less sensitive than fish and no further long-term test with invertebrates is needed.
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