Registration Dossier
Registration Dossier
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EC number: 639-864-4 | CAS number: 43133-95-5
Endpoint summary
Administrative data
Description of key information
Two key 90 day repeat dose inhalation studies were conducted for commercial hexane (API, 1990; Klimisch score =2).
Key value for chemical safety assessment
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- LOAEC
- 10 504 mg/m³
- Study duration:
- subchronic
- Species:
- rat
Additional information
In a key read across sub-chronic toxicity study of commercial hexane, groups of 10 male and 10 female rats were exposed to concentrations of 0, 904, 2984, and 8992 ppm of test substance for 6 hrs/day, 5 days/week, for 13 weeks via the inhalation route (API, 1990; Klimisch score =2).
There was no mortality among the exposed groups, and no treatment related effects to body weight gain. At sacrifice hemorrhage and inflammation in high dose male livers were considered the only possible treatment related effects. The significance of this effect is uncertain. The NOAEC for male rats in 2984 ppm, and the LOAEC is 8992 ppm (10504 mg/m3). The NOAEC for female rats in 8992 ppm (31652 mg/m3).
In a similar key read across sub-chronic toxicity study of commercial hexane, groups of 10 male and 10 female mice were exposed to concentrations of 0, 904, 2,984, and 8,992 ppm of test substance for 6 hrs/day, 5 days/week, for 13 weeks, via inhalation (API, 1990; Klimisch score =2). Seven animals died during the study, however, all deaths were accidental and not considered treatment related. The NOAEC for mice is 8992 ppm (31652 mg/m3).
Repeated dose toxicity: inhalation - systemic effects (target organ) digestive: liver
Justification for classification or non-classification
This substance is not classified for repeat dose toxicity based on the negative results of the key read across studies.
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