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Diss Factsheets
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EC number: 212-073-8 | CAS number: 759-94-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This animal study is not performed according to GLP, but the test parameters are well documented and scientifically acceptable.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Hungarian authority requirements: MÉM Agrokémiai Főosztály
- Principles of method if other than guideline:
- Methods in Toxicology ( 19709 Balazs, T. Blackwell Scientific Publ. Oxf.-Edinburgh, 49-81.
Zbinden, G. and Flury-Roversi, M. (1981) Archives of Toxicology , 47, 77-99.
Finney, D.J (1952) Probit Analysis. Cambridge, Univ. Press - GLP compliance:
- no
- Test type:
- other: Hungarian authority requirements: MÉM Agrokémiai Főosztály
Test material
- Reference substance name:
- EPTC
- EC Number:
- 212-073-8
- EC Name:
- EPTC
- Cas Number:
- 759-94-4
- Molecular formula:
- C9H19NOS
- IUPAC Name:
- N,N-dipropyl(ethylsulfanyl)formamide
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: PVG/C, SPF
- Sex:
- male
Administration / exposure
- Route of administration:
- other: intraperitonealis szabad hasüregbe történő bejuttatás
- Vehicle:
- not specified
- Doses:
- Dózis ( mg / kg): 0, 475, 570, 665, 760, 808, 855
- No. of animals per sex per dose:
- 4 male / dose
- Control animals:
- yes
Results and discussion
- Preliminary study:
- Doses: 23.7, 47.5, 71.2, 95.0, 118.8, 142.5, 237.5, 475.0, 950.0 -died a female, 1900.0 -died both , 3800.0 - died both
2 animals ( male and female)/doses
ALD = 950 mg/ bw-kg
Acute toxicity study is needed.
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 760 mg/kg bw
- Based on:
- not specified
- 95% CL:
- ca. 656 - 874
- Mortality:
- At 0 mg/kg dose 0 died out of 4 rats.
At 475 mg/kg dose 1 died out of 4
At 570 mg/kg dose 2 died out of 4
At 665 mg/kg dose 2 died out of 4
At 760mg/kg dose 3 died out of 4
At 808 mg/kg dose 4 died out of 4
At 855 mg/kg dose 4 died out of 4 - Clinical signs:
- other: Status: Néhány óra alatt kialakuló toxikus tünetek követik a parenteralis bevitelt. Rendkívüli levertség, tónustalanság, időnkénti görcsös rángások jellemzőek. Az elhullások 12-24 órán belül következnek be. A túlélő állatok állapota rendkívül lassan rend
- Gross pathology:
- Bonclelet: Az akut stádiumban elhullott állatok mellűri statusa negatív, az abdominalis status az irritalt peritoneum jellegzetes képét mutatja. Belövelt abdominalis zsigerek, erezett, lobos peritoneum, kismértékben megnagyobbodott máj. A túlélő állatokban az irritáció következtében peritonitis alakul ki, amely a szokásos képpel, - ascites, összenövések- járt.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 760 mg/ bw-kg this is acut toxicity category IV (between the cat IV limit 300-2000) Acut tox Category 4 H302
- Executive summary:
According to this study the LD50 of EPTC is 760 mg/bw-kg. ( rat, male) Acut tox Category 4 H302
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