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EC number: 208-063-8 | CAS number: 507-09-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Thioacetic acid was slightly irritant when applied topically to rabbits and severely irritant when instillated in the eyes of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
The potential of THIOACETIC ACID to induce skin irritation was evaluated in rabbits according to O.E.C.D. (No. 404, 17th July 1992) and E.C. (92/69/E.E.C., B4, 31 st July 1992) guidelines (Manciaux, 1998). The study was conducted in compliance with the Principles of Good Laboratory Practice Regulations. The test substance was applied in a first assay for periods of 3 minutes and 4 hours to one male New Zealand White rabbit. Since the test substance was not strongly irritant in this first assay, it was applied for 4 hours to two other males in a second assay. A single dose of 0.5 ml of the test substance in its original form was applied to the closely clipped skin of one flank. The test substance was held in contact with the skin by means of a semi-occlusive dressing. Cutaneous reactions were observed approximately 1 hour, 24, 48 and 72 hours after removal of the dressing and the end of the observation period.The mean values of the scores for erythema and oedema were calculated for each animal.After a 3-minute exposure (one animal), no cutaneous reactions were observed during the study. After a 4-hour exposure (three animals), a well-defined erythema was observed in ail animals on day 1; it persisted up to day 11 at the latest.A slight oedema was noted in ail animals from day 1 or 2; it persisted for 24, 48 or 72 hours.Dryness of the skin was recorded in ail animals from day 5 or 6 up to day 12, 13 or 15. A slight yellow colouration of the skin was also observed in ail animals between day 1 and day 4. Mean scores over 24, 48 and 72 hours for each animal were 2.0, 1.7 and 1.7 for erythema and 2.0, 0 and 0 for oedema.
Eye irritation
The potential of THIOACETIC ACID to induce ocular irritation was evaluatedin rabbits according to OECD (No. 405, 24th February 1987) and EC (92/69/EEC, B.5, 31 st July1992) guidelines (Manciaux, 1999). The study was conducted in compliance with the principles of Good Laboratory Practice Regulations. As possible irritant effects were anticipated, a first assay was conducted in one male New Zealand White rabbit. Since the test substance showed severe irritant properties in this first assay, the study was considered complete and the test substance was not evaluated in other animals. A single dose of 0.1 ml of the undiluted test substance was instilled into the left conjunctival sac. The right eye served as control. The eyes were not rinsed after administration of the test substance. Ocular reactions were observed approximately 1 hour, 24, 48 and 72 hours after the administration. The mean values of the scores for chemosis and corneal opacity were calculated. Slight or moderate conjunctival reactions (slight or moderate chemosis, whitish coloration of the conjunctivae and clear to whitish purulent discharge) were observed between day 1 and day 4. A moderate corneal opacity was recorded between day 1 and day 4; the scoring of iritis was masked by this important corneal opacity. In the view of these ocular reactions, the animal was killed on day 4 for ethical reasons. Mean scores calculated over 24, 48 and 72 hours were 3.0 for chemosis and 3.0 for corneal opacity. Other scores were not calculable. THIOACETIC ACID is severely irritant when administered by ocular route to rabbits.
Justification for selection of skin irritation / corrosion endpoint:
Key study
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: highly irritating
Justification for classification or non-classification
Skin irritation:
Mean scores over 24, 48 and 72 hours for each animal were 2.0, 1.7 and 1.7 for erythema and 2.0, 0 and 0 for oedema
in a key study. On this basis and in accordance with Regulation (EC) No 1272/2008 and Annex VI of Commission Directive 2001/59/EC, thioacetic acid was slightly irritant but does not merit classification as a skin irritant.Eye irritation:
Mean scores calculated over 24, 48 and 72 hours were 3.0 for chemosis and 3.0 for corneal opacity. Other scores were not calculable
. On this basis and in accordance with Regulation (EC) No 1272/2008, thioacetic acid was classified as irritating to eyes 1 (Hazard statement H318: Causes serious eye damage) and in accordance with Annex VI of Commission Directive 2001/59/EC, thioacetic acid was classified as irritant with the symbol Xi and the phrase ‘R41 Risk of serious damage to eyes’.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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