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Diss Factsheets
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EC number: 203-224-9 | CAS number: 104-66-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on developmental toxicity
Additional information
- Reproduction/Developmental Oral Toxicity Screening Test of KS-235 in Wistar Rats:
Results: Dose formulations at each dose concentration was within the acceptance level of ± 10.0 % of nominal concentration and CV% < 10% which indicates that the dose formulation prepared were homogeneous. No mortality was observed in parental rats. No treatment related clinical sign and mortality was observed in pups. Transient salivation (approximately 15 to 20 minutes) was observed in post dosing parental rats treated with KS-235 at 250 and 1000 mg/kg b. wt./day dose groups. Body weight of parental rats was statistically significantly lower during experimental period at 1000 mg/kg b. wt./day dose group when compared with the control group. The percent body weight change, feed consumption and fertility data were comparable between control and all KS-235 the treated groups. No treatment related macroscopic/microscopic finding was observed across all the groups.
Conclusion: On the basis of the results obtained in the present study, it is concluded that though their was transient salivation and body weightreduction at 1000 mg/kg b. wt./day KS-235, but KS-235 did not produce adverse effect in reproduction and development up to the dose level of 1000 mg/kg b. wt./day when administered through oral gavage in Wistar rats prior to mating, during mating, post-mating, gestation period and until post-partum day 3.
Justification for classification or non-classification
Additional information
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