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Diss Factsheets
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EC number: 220-150-2 | CAS number: 2643-07-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro studies:
The test substance was tested for mutagenicity in a combined Ames test equivalent or similar to OECD TG 471 and E. coli bacterial reverse mutation assay equivalent and similar to OECD TG 472. The test substance was mutagenic with S. typhimurium strain TA 100, but not with the other test strains (S. typhimurium TA 1537 and TA 98; E.coli WP2 uvrA). In the presence of S-9 mix, the mutagenicity with S. typhimurium TA 100 was potentiated and the compound became also mutagenic with E. coli WP2 uvrA and slightly with S. typhimurium TA 98 (BASF AG, 1980).
The test substance was asessed for its potential to induce gene mutations at the hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus in Chinese hamster ovary (CHO) cells in vitro. This test was performed according to OECD TG 476 in compliance with GLP. Following the results of this study, the test substance is considered to induce forward mutations in the HPRT locus assay under in vitro conditions in CHO cells in the absence of metabolic activation (BASF SE, 2010).
In a GLP guideline study according to OECD TG 473 the test substance was considered to have a chromosome-damaging (clastogenic) effect under in vitro conditions in V79 cells in the presence of metabolic activation (BASF SE, 2009).
In vivo studies:
No studies are available for assessment.
Short description of key information:
Genetic toxicity in vitro:
- Ames test: positive
- HPRT test: positive
- Chromosomal aberration test: positive
Endpoint Conclusion:
Justification for classification or non-classification
EU classification according to Annex VI of the Directive 67/548/EEC:
- Possible risk of irreversible effects, R68 (Muta. Cat. 3)
GHS classification according toAnnex I 1272/2008 CLP (EU GHS):
- Muta. Cat. 2
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.