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EC number: 221-209-5 | CAS number: 3031-66-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritating potential of the test substance was assessed in three in vivo skin irritation studies. Slight to moderate erythema and edema were observed, not fully reversible within 8 days. Therefore, the test substance is considered to be a skin irritant.
The test substance causes severe eye damage in the available eye irritation studies in vivo.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: early study report, essential details given
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- unchanged solidified test substance
- Duration of treatment / exposure:
- single exposure
- Observation period:
- 24 h, 8 days
- Number of animals:
- 2
- Details on study design:
- SCORING SYSTEM: BASF internal standard. Scores were transfered to Draize Scoring System
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24/48/72 h
- Score:
- ca. 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- after 8 d
- Remarks on result:
- other: after 20h exposure period
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24/48/72h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- after 8 d
- Remarks on result:
- other: after 20h exposure period
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24/48/72h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: after 20h exposure period
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24/48/72h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: after 20h exposure period
- Irritant / corrosive response data:
- No effect 1, 5 and 15 min after application
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: early study report, essential details given
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of the same animal
- Amount / concentration applied:
- 50 mg
- Duration of treatment / exposure:
- single exposure
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- SCORING SYSTEM: BASF internal standard. Scores were transfered to Draize Scoring System
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 24/48/72h
- Score:
- ca. 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Staphyloma
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- other: 24/48/72h
- Score:
- ca. 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Staphyloma
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24/48/72h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 24/48/72h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 24/48/72h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: 24/48/72h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 24/48/72h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: bleedings
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- other: 24/48/72h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation/corrosion
The test item was assessed for skin irritating properties in a study performed in rabbits (BASF, 1971). After 20 hours of test substance exposure slight to moderate erythema and edema were observed and the erythema score was determined to be 2 and 3 in animal 1 and 2, respectively, not fully reversible after 8 days. Therefore, the test substance was considered to be irritating to the skin.
This evaluation is supported by further non standard skin irritation studies available. In both studies (BASF, 1973,1958) slight irritating properties to the skin of rabbits were noted. A clear evaluation with regard to classification and labelling was not possible in these supporting non standard studies.
Eye irritation
The test item was assessed for eye irritating properties in a non-GLP study performed in rabbits. Based on the results of the key study (BASF, 1971), the substance was considered as severely eye damaging (cornea score: 3, conjunctivae score: 2, chemosis score: 2). The results of the key study were confirmed by two supporting non-GLP studies (BASF, 1973,1958) performed in rabbits, revealing eye damaging properties of the test item.Justification for selection of skin irritation / corrosion endpoint:
Most current in vivo study.
Justification for selection of eye irritation endpoint:
Most current in vivo study.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: highly corrosive
Justification for classification or non-classification
- R38 Irritating to the skin (according to Directive 67/548/EEC).
- H315 Causes skin irritation, Cat.2 (according to Regulation (EC) No 1272/2008).
Based on the results obtained in the eye irritation tests, the test item is classified as follows:
- R41 Risk of serious damage to eyes (according to Directive 67/548/EEC).
- H318 Causes serious eye damage, Cat.1 (according to Regulation (EC) No 1272/2008).Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.