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EC number: 214-068-6 | CAS number: 1076-97-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- test material is applied to 6 rather than 3 rabbit eyes; test material is removed (washed) from 3 of 6 eyes, to evaluate the effect of washing on subsequent development of irritant response
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cyclohexane-1,4-dicarboxylic acid
- EC Number:
- 214-068-6
- EC Name:
- Cyclohexane-1,4-dicarboxylic acid
- Cas Number:
- 1076-97-7
- Molecular formula:
- C8H12O4
- IUPAC Name:
- cyclohexane-1,4-dicarboxylic acid
- Details on test material:
- several crystals; dry
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- several crystals
- Duration of treatment / exposure:
- acute
- Observation period (in vivo):
- 10 days
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- other: group
- Time point:
- other: 1 hour
- Score:
- 2
- Reversibility:
- fully reversible
- Remarks on result:
- other: 2=moderate irritation
- Irritation parameter:
- overall irritation score
- Basis:
- other: group
- Time point:
- other: 24 hours
- Score:
- 2
- Reversibility:
- fully reversible
- Remarks on result:
- other: 2=moderate irritation
- Irritation parameter:
- overall irritation score
- Basis:
- other: group
- Time point:
- other: 48 hours
- Score:
- 1
- Reversibility:
- fully reversible
- Remarks on result:
- other: 1=slight irritation
- Irritant / corrosive response data:
- In the eye of rabbits exposed to test article without subsequent washing, 3 of 3 demonstrated moderate irritation of the conjunctiva and nicitating membrane at 1 and 24 hours after exposure; at 24 hours, irritation was accompanied by moderate corneal opacity, and positive adnexa and corneal staining was observed in 3 of 3 eyes. At 48 hours after exposure, slight irritation was observed in 3 of 3 eyes, accompanied by moderate corneal opacity. At 7 days after exposure, irritation was present in 2 of 3 eyes, wherein slight irritation was accompanied by slight corneal opacity. At 10 days after exposure, 3 of 3 eyes appeared normal.
In eyes of rabbits exposed to test article followed by washing, slight irritation was observed in the conjunctiva and nicitating membrane in 3 or 3 eyes at 1, 24, and 48 hours after exposure. At 24 hours after exposure, positive adnexa staining was observed in 3 of 3 eyes, while corneal staining was not observed. At 7 and 10 days after exposure, 3 of 3 eyes appeared normal.
Applicant's summary and conclusion
- Conclusions:
- moderate eye irritant; washing was palliative
- Executive summary:
The test article (1,4 - cyclohexane dicarboxylic acid; CHDA) was instilled into both eyes of 3 rabbits, and for each rabbit, the test article was removed from one eye by washing. Each eye was evaluated for evidence of irritation at 1, 24, and 48 hours after instillation, and after 7 and 10 days. In the unwashed eyes, moderate irritation was observed in 3 of 3 eyes at 1 and 24 hours after instillation, and slight irritation was observed in 3 of 3 eyes at 48 hours after instillation. Irritation was accompanied by moderate corneal opacity at 24 and 48 hours after instillation and by slight corneal opacity after 7 days. By 10 days after test article instillation, 3 of 3 eyes appeared normal. In the washed eyes, slight irritation was observed in 3 of 3 eyes at 1, 24, and 48 hours after instillation, and by 7 days after test article instillation,3 of 3 eyes appeared normal.
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