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Diss Factsheets
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EC number: 234-456-9 | CAS number: 12004-39-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
A key study is provided for the assessment of growth inhibition in algae. The study was conducted in accordance with the appropriate OECD test guideline, with analytical confirmation of exposure concentrations, with no deviations and in compliance with GLP. The 72-hour EC50 was found to be >0.210 mg/L and the NOEC was determined to be 0.210 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 0.21 mg/L
- EC10 or NOEC for freshwater algae:
- 0.021 mg/L
Additional information
Key study
The inhibitory effect of dialuminium titanium pentaoxide on algal growth was determined in a 72 hour growth inhibition test withPseudokirchneriella subcapitata, conducted in accordance with OECD guideline 201. The algae were exposed to the test substance at loading rates of 0 (control), 10, 18, 32, 56 and 100 mg/L. Concentrations of dissolved aluminium and titanium were determined by ICP-MS which were then used to calculate equivalent concentrations of the test substance present in the test solutions. Test media were not renewed during the 72 hours.
The 72hr ErC50 based on aluminium analysis was determined to be >0.388 mg/L. The 72hr ErC50 based on titanium analysis was determined to be >0.274 mg/L in the standard growth medium and >0.210 mg/L in the enhanced growth medium. The 72hr NOECr based on titanium analysis was determined to be 0.210 mg/L in enhanced growth medium.
The NOECr for the standard medium occurred at the 10 mg/L loading rate, while the NOEC for the enhanced medium occurred at 100 mg/L. As concentrations of test substance measured were comparable in the 100 mg/L treatments of both the standard and enhanced media, it was suggested that the effect of the test substance in the standard medium was due to decreased bioavailability of nutrients caused by aluminium and titanium forming complexes with components of the test media. This is not considered to be a toxicological effect and as such is not used for derivation of NOEC of endpoints.
No unusual cell shape or agglutination was observed at any test concentration after 72 hours.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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