Registration Dossier
Registration Dossier
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EC number: 939-725-0 | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referenced sources in an international report.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Dimethylformamide, SIDS Initial Assessment Report For SIAM 13
- Author:
- OECD
- Year:
- 2 001
- Bibliographic source:
- UNEP PUBLICATIONS
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 79/831/EEC corresponding to OECD 202
- GLP compliance:
- yes
Test material
- Reference substance name:
- N,N-dimethylformamide
- EC Number:
- 200-679-5
- EC Name:
- N,N-dimethylformamide
- Cas Number:
- 68-12-2
- Molecular formula:
- C3H7NO
- IUPAC Name:
- N,N-dimethylformamide
- Test material form:
- not specified
- Details on test material:
- 99.8 % purity
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Details on test solutions:
- test volume: 10 ml, dilution factor: 2
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- age of test animals: 2 - 24 hours,
number of animals/vessel: 5,
total number of animals/concentration: 20,
number of replicates and controls/concentration: 4.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- not applicable
Test conditions
- Hardness:
- no data
- Test temperature:
- 19.8 - 20.5 °C
- pH:
- 7.8 - 8.0
- Dissolved oxygen:
- 8.1 - 8.8 mg/l
- Salinity:
- no data
- Nominal and measured concentrations:
- 100 - 12.5 mg/l
- Details on test conditions:
- illumination: artificial light, day:night-rhythm = 16:8 hours light intensity: appr. 5-6 µE/m²*s at 400 - 700 nm
- Reference substance (positive control):
- not specified
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- no data
- Results with reference substance (positive control):
- no data
- Reported statistics and error estimates:
- no data
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- In short term tests with daphnids, DMF showed an EC50 >100 mg/l. Hence, DMF is not harmful to daphnia magna.
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