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Diss Factsheets
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EC number: 939-647-7 | CAS number: 1474044-68-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1963
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was conducted prior to the implementation of current testing guideline and GLP; nevertheless, the test conduct in principle was similar to the OECD TG 401 and thus, acceptable. The study was performed on an analogue substance (for justification of read-across, please refer to the corresponding assessment report in Section 13).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium N-(2-carboxyethyl)-N-dodecyl-β-alaninate
- EC Number:
- 239-032-7
- EC Name:
- Sodium N-(2-carboxyethyl)-N-dodecyl-β-alaninate
- Cas Number:
- 14960-06-6
- IUPAC Name:
- Sodium Lauriminodipropionate
- Test material form:
- other: liquid
- Details on test material:
- - Common name : Sodium lauriminodipropionate
- For more details, see below the Confidential details for test material
Constituent 1
- Specific details on test material used for the study:
- Form: aqueous solution
The study was performed on a commercial product (aqueous solution) as the test item is manufactured and used in a liquid form.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not specified
- Weight at study initiation: approx. 130 g
- Fasting period before study: 16 hours (food withdraw)
- Housing: individually in stock cages
- Diet: Standard laboratory rat diet (Rockland Rat Diet, Rockland Farms, New City, New York), ad libitum
- Water: ad libitum
- Acclimation period: 5 days
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 15400, 23100, 34600 and 51900 mg/kg bw (calculated doses of the undiluted test material)
- No. of animals per sex per dose:
- 2/sex/group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: particular attention was given to observation for mortalities and clinical symptoms during the first 4 hours following treatment.
- Necropsy of survivors performed: not specified - Statistics:
- The LD50 was calculated using the techniques of Weil CS (Tables for convenient calculation of median-effective dose (LD50 or ED50) and instructions in their use. Biometrics 8: 249-263, 1952), Thompson WR (Use of moving averages and interpolation to estimate median-effective dose. Bact Rev Nov 1947), and Thompson & Weil (On the construction of tables for moving average interpolation. Biometrics, March 1952).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 31 300 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 100% (4/4) mortality was observed at 51900 mg/kg bw
50% (2/4) mortality was observed at 34600 mg/kg bw
25% (1/4) mortality was observed at 23100 mg/kg bw
no mortality occurred at 15400 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified - Executive summary:
For assessment of the acute oral toxicity, sodium lauriminodipropionate as a 10% active ingredient solution in water, was administered by single gavage to rats, at dose levels of 15400, 23100, 34600 and 51900 mg/kg bw. Each test group comprised 2 male and 2 female animals, observed for 14 days. The testing method in principle was similar to the OECD TG 401.
The following results were obtained:
- 100% (4/4) mortality was observed at 51900 mg/kg bw;
- 50% (2/4) mortality was observed at 34600 mg/kg bw;
- 25% (1/4) mortality was observed at 23100 mg/kg bw;
- No mortality occurred at 15400 mg/kg bw.
The LD50 was therefore calculated to be 31300 mg/kg bw.
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