Registration Dossier
Registration Dossier
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EC number: 222-103-1 | CAS number: 3349-36-8
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
The study was considered to be not technically feasible according to the information provided in the Butler & White, 2010 study due to rapid hydrolyses of the test substance, as demonstrated in a water solubility study.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4
- at the temperature of:
- 25 °C
Additional information
- During preliminary investigations for the water solubility test, it was observed that the test item hydrolysed almost immediately on contact with water. Substances which hydrolyse rapidly in contact with water are not suitable for determination using Method 107.
- Estimation using the ratio of the solubility of the test item in n-octanol and water would also be unreliable due to the rapid hydrolysis of the test item in the water.
- The partition coefficient determination using the HPLC method, Method 117 of the OECD Guidelines for Testing of Chemicals, was unsuitable since organometallic materials are known to react with HPLC columns."
In accordance with Annex XI section 2 of the Regulation EC 1907/2006, testing for a specific endpoint may be omitted, if it is technically not possible to conduct the study as a consequence of the properties of the substance.
The following statement was included in a physico-chemical properties study by Butler & White (2010) concerning the feasibility of a partition coefficient study on the test substance:
"No determination was performed using the shake-flask method, designed to be compatible with Method 107 of the OECD Guidelines for Testing of Chemicals, 27 July 1995for the following reasons:
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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