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EC number: 271-230-9 | CAS number: 68526-82-9 The high boiling residuum from the distillation of C7-11 alcohols.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Summray from a publically available document.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Alkenes, C6-10, hydroformylation products, high boiling.
- Author:
- BASF Corporation
- Year:
- 2 003
- Bibliographic source:
- U.S. EPA HPV Challenge Program Submission
Materials and methods
Test material
- Reference substance name:
- Alkenes, C6-10, hydroformylation products, high-boiling
- EC Number:
- 271-230-9
- EC Name:
- Alkenes, C6-10, hydroformylation products, high-boiling
- Cas Number:
- 68526-82-9
- Molecular formula:
- None available
- IUPAC Name:
- None available - not a single isomer - see remarks
Constituent 1
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Executive summary:
A subchronic aerosol inhalation study of CAS# 68526 -82 -6 was conducted in 1987 (24). Groups of 15 Sprague-Dawley rats of each sex were exposed to atmospheres containing the test substance six hours a day, five days a week for 13 weeks. The target levels of test substance were 0, 100, 300, and 1000 mg/m3 and the achieved concentrations were very near target levels. Clear treatment related effects were observed in rats from the high-dose group manifest as reduced body weight gains, increased lung weights and microscopic pulmonary morphology. Mid-dose group animals exhibited an increase in lung weigh only for males and microscopic effects that were considered by the examining pathologist to be indicative of a “physiological response to aerosol exposure” and of questionable toxicological significance. In light of the dose-response continuum and minimal microscopic effects at the low dose, the mid dose is considered a LOAEL and the low dose is considered a NOAEL. The only target organ identified was the respiratory tract where necrosis of olfactory-respiratory epithelium was observed in numerous treated animals but not in controls. Additionally, mid and high-dose animals showed interstitial inflammation of the lungs in rats. No changes attributed to treatment in any organ system related to reproductive function were mentioned in the laboratory report although most reproductive organs from high dose and control animals underwent macroscopic and microscopic evaluation.
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