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EC number: 204-984-4 | CAS number: 130-26-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Stability
Phototransformation in air
The atmospheric oxidation half-life of clioquinol was estimated using the level III multimedia model. It was estimated that the substance is not persistent in air medium as the half life period of clioquinol in air is only 1.9 days. This indicates that clioquinol is rapidly phototransformed in air.
OVERALL OH Rate Constant =0.0000000000086cm3/molecule-sec.
Media |
Half life (days) |
Percent in Medium |
Air |
1.9 |
0% |
Hydrolysis:
The Hydrolysis rate constant of clioquinol is estimated to be 0.0000000000085559 cm3/molecule-sec. at half life of 15.002 hrs.The estimated half life of the substance indicates that the substance is moderately hydrolysable.
Phototransformation in water
No experimental data available. As this study is not a standard information requirement in REACH and there is no indication from the CSA on the need to investigate further the fate and behaviour of the substance (Annex X requirement), no further testing is considered necessary.
Phototransformation in soil
No experimental data available. As this study is not a standard information requirement in REACH and there is no indication from the CSA on the need to investigate further the fate and behaviour of the substance (Annex X requirement), no further testing is considered necessary.
Biodegradation
Biodegradation in water
The half life period ofclioquinolin water is 38 days and based on this value it can be concluded that the chemical is not persistent in water medium since the half life is less than the threshold of 60 days (to qualify the chemical as persistent). Also the diffusion percentage ofclioquinolin water medium is 11%. This coupled with the dilution of water shall result in ready biodegradabililty of the chemical.
The supporting study also shows the half life of clioquinol to be 900 hrs (37.5 days) indicating thet it is readily biodegradable
Media |
Half-Life |
Percent in |
Water |
38 |
11% |
Media |
Half life (hrs) |
Percent in Medium |
Emission (kg/hr)
|
Water |
900 |
10.8 |
1000 |
Biodegradation in water and sediment
Based on the Level III Fugacity Model, the half life period of theclioquinolwas estimated. The half period ofclioquinolin water is 38 days (912 hrs) therefore it is considered that the substance will qualify as not persistent as the half life does not exceed the threshold of 60 days. So, it can be confirmed that the substance is readily biodegradable in water medium where as in sediment the half life is 340 days (8160 hrs).
Based on this value, it can be inferred that the substance is persistent in sediment medium and is not readily biodegradable probably due to the anaerobic conditions existing in most sediments. However, it can be observed that clioquinol have very slightdiffusion in the sediment medium since it's percentage in the sediment medium is reported to be 3% and hence persistence in the sediment compartment is not likely to be critical.
Media |
Half-Life |
Percent in |
Water |
38 |
11% |
Sediment |
340 |
3 % |
Media |
Half life (hrs) |
Percent in Medium |
Emission (kg/hr)
|
Water |
900 |
10.8 |
1000 |
Sediment |
8100 |
3.38 |
0 |
Biodegradation in soil
The PBT Profiler & EPI Suite has estimated thatclioquinolis expected to be found predominantly in soil and its persistence estimate is based on its transformation in this medium. Its half-life in soil, 75 days (1800 hrs). This exceeds the threshold of >= 2 months (and <= 6 months). Therefore,clioquinolis estimated to be persistent in the soil environment.
PBT profiler estimate
Media |
Half-Life |
Percent in |
Soil |
75 |
86% |
Fugacity Model by EPI Suite estimation database
|
Mass Amount (percent) |
Half-Life (hr) |
Emissions (kg/hr) |
soil |
85.9 |
1.8e+003 |
1000 |
Bioaccumulation: aquatic/sediment
Bioaccumulation is the process by which the chemical concentration in an aquatic organism achieves a level that exceeds that in the water, as a result of chemical uptake through all possible routes of exposure.The relationship between bioaccumulation and bio-concentration is that, chemicals that have the potential to bioconcentrate also have the potential to bioaccumulate. Bioaccumulation is closely related to the Bioconcentration factor (BCF).
The estimated BCF of the key study was obtained to be 91.Supporting study also indicate the same BCF value. This low value of BCF of clioquinol indicates its non bioaccumulative nature as the BCF factor is less than the bio-concentration threshold of 2000.
Transport and distribution
Adsorption/Desorption
Soil Adsorption Coefficient i.e Koc value of clioquinol was estimated as 5425 L/kg (Log koc = 3.7343) at 25 deg C by means of MCI method. This indicates that clioquinol will have strong tendency of sorption to soil and sediment and therefore have negligible migration potential to groundwater.
This Koc value when converted at 20 degC is equivalent to 4340.
Henry's Law constant
Henry's Law states that at a constant temperature, the amount of a given gas that dissolves in a given type and volume of liquid is directly proportional to the partial pressure of that gas in equilibrium with that liquid.Henry’s law constant of clioquinol was estimated to be 0.00000125 (1.25E-006) Pa m³/mol at 25 degC.
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