Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-137-3 | CAS number: 1305-62-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Tested material CRCD consisted of 15-25 % Ca-hydroxide only.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Neurotoxic effect of two root canal sealers with calcium hydroxide on rat phrenic nerve in vitro
- Author:
- Boiesen J and Brodin P
- Year:
- 1 991
- Bibliographic source:
- Endod. Dent. Traumatol. 7: 242-245
- Reference Type:
- secondary source
- Title:
- Neurotoxic effect of two root canal sealers with calcium hydroxide on rat phrenic nerve in vitro
- Author:
- Boiesen J and Brodin P
- Year:
- 1 991
- Bibliographic source:
- cited in: Consensus Report for Calcium Oxide and Calcium Hydroxide, February 24, 1999
Materials and methods
- Type of study / information:
- in vitro treatment of rat phrenic nerves
Test material
- Reference substance name:
- Calcium dihydroxide
- EC Number:
- 215-137-3
- EC Name:
- Calcium dihydroxide
- Cas Number:
- 1305-62-0
- Molecular formula:
- CaH2O2
- IUPAC Name:
- calcium dihydroxide
- Details on test material:
- Test material CRCS consisted of 15-25% Calcium hydroxide and 30% Zinc oxide
Constituent 1
Results and discussion
Any other information on results incl. tables
Root canal sealers placed into contact with the inferior alveolar nerve can cause paraesthesia in the area innervated by this nerve. The paraesthesia is due to neurotoxic effects of the sealers. In this study we examined the effect on nerve conduction in vitro of two calcium hydroxide-containing root canal sealers, Sealapex and CRCS. An isolated rat phrenic nerve was placed between two suction electrodes in a bath containing Tyrode solution. The sealers were brought into contact with the nerve, and the evoked compound action potentials (cAP) were recorded before and after contact with the materials. Both Sealapex and CRCS induced a fast and complete inhibition of the cAP in this model. The degree of reversibility of the inhibition varied from experiment to experiment. Both materials exhibited reversible and irreversible block of the nerve conduction after 90s and 5 min exposure. However, after 30 min of contact, the conduction of the cAP was irreversibly blocked for both materials.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.