Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 800-153-0 | CAS number: 1313206-64-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- No substance identification; only "EC 63". No QA / GLP. Deviations from the current OECD402 guideline; 2 animals were used per sex per dose group in stead of 5. Half of the animals had abraded skin.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- : Only 2 animals per sex per dose group were used, 4 animals in total, in stead of 5. Half of the animals had abraded skin.
- Principles of method if other than guideline:
- See deviations
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- N-C16-18-alkyl-(evennumbered) C18 unsaturated) propane-1,3-diamine
- EC Number:
- 629-719-3
- Cas Number:
- 1219010-04-4
- Molecular formula:
- CnH2n+1-NH-C3H6-NH2 and CnH2n-NH-C3H6-NH2
- IUPAC Name:
- N-C16-18-alkyl-(evennumbered) C18 unsaturated) propane-1,3-diamine
- Details on test material:
- Chemical registery number : 1219010-04-4
Chemical name : N-C16-18 (even numbered) and C18 (unsaturated) alkyl propane-1,3-diamine
Based on the qualitative and quantitative information on the composition, the sample used are representative of the boundary composition shared and agreed by each registrant.
1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 2.13-3.00 Kg
- Fasting period before study: no data
- Housing: animals were caged individually
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): approximately 18
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: No data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- propylene glycol
- Details on dermal exposure:
- TEST SITE
- Area of exposure: trunk of the animals
- % coverage: 10
- Type of wrap if used: The treated area was covered with a thin layer of cellulose sheet and wrapped in polyethylene foil .
REMOVAL OF TEST SUBSTANCE
- Washing (if done): test substance was removed from the skin with water and the animals were wiped dry with towels.
- Time after start of exposure: 24h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.0 (control), 0.7, 1.4 and 2.0 g/kg body weight.
- Concentration (if solution): no data
- Constant volume or concentration used: yes; 9 ml/kg body
VEHICLE
- Amount(s) applied (volume or weight with unit): 9 ml/kg body
- Concentration (if solution): no data
- Lot/batch no. (if required): no data
- Purity: no data - Duration of exposure:
- 24h
- Doses:
- 0.0 (control), 0.7, 1.4 and 2.0 g/kg body weight.
- No. of animals per sex per dose:
- 2
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily observations and weighing at the start of the study and after week 1 and 2
- Necropsy of survivors performed: yes
- Other examinations performed: examinations were carried out for possible changes in blood composition and for macroscopic appear of severak organs, water and food consumption were measured.
Results and discussion
Effect levels
- Key result
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortality occured.
- Clinical signs:
- other: No clinical signs were observed.
- Gross pathology:
- Gross examination at autopsy did not reveal any treatment-related changes.
- Other findings:
- Haematological data were comparable for all groups.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- From the present results it is concluded that the product EC 63 is practically non-toxic in the case of one single dermal application. LD50 > 2000 mg/kg bw
- Executive summary:
There is no substance identification; only "EC 63".
No QA / GLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.