Registration Dossier
Registration Dossier
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EC number: 700-239-7 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
- GLP compliance:
- yes
Test material
- Reference substance name:
- L-733,650-000V002
- IUPAC Name:
- L-733,650-000V002
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Amount / concentration applied:
- 100 mg into the left conjunctival sac
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: moderate conjunctival redness and discharge and very slight chemosis
- Basis:
- mean
- Time point:
- other: 15 minutes
- Irritation parameter:
- other: Discharge increased to severe in one eye
- Basis:
- mean
- Time point:
- other: 2 hours
- Irritation parameter:
- other: Discharge increased to severe in another eye
- Basis:
- mean
- Time point:
- other: 24 hours
- Irritation parameter:
- other: A crusty brown material was observed in the discharge of two eyes
- Basis:
- mean
- Time point:
- other: 24 hours
- Irritation parameter:
- other: Congestion of the iris was seen in one eye
- Basis:
- mean
- Time point:
- other: 24 hours
- Irritation parameter:
- other: Ocular changes began to diminish
- Basis:
- mean
- Time point:
- other: within 48 hours
- Irritation parameter:
- other: Ocular changes were gone
- Basis:
- mean
- Time point:
- other: by 7 days
Any other information on results incl. tables
Moderately irritating to eyes
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
