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EC number: 229-494-8 | CAS number: 6574-99-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2008
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- There is no data available acute dermal toxicity testing with 3,4-Dichlorobenzonitrile. In order to classify the substance according to GHS relevant endpoint data available for 2,6-Dichlorobenzonitrile was read-acrossed to 3,4-Dichlorobenzonitrile based on structural similarities. 2,6-Dichlorobenzonitrile is as well as 3,4-Dichlorobenzonitrile, is a disubstituted Benzonitrile. Both substances only differ in the position of the chloro substituents. Furthermore both substances are solid, practically insoluble in water and have a water octanol partition coefficient of 2.2 and 2.8. This might perhaps also lead to a similiar dermal resorption of the substnces and therefore a similar toxicological behavior. In order to gain more information about 3,4-Dichlorobenzonitrile and to classify the substance (without any unneccessary animal testing) according to GHS the result of the acute dermal test with 2,6-Dichlorbenzonitrile was read acrossed.
For justsification of Read Across see section 13.2
Data source
Referenceopen allclose all
- Reference Type:
- other: Chemical Toxicity Database
- Title:
- No information
- Year:
- 2 008
- Bibliographic source:
- RTECS number-DI3500000-Chemical Toxicity Database (www.drugfuture.com/toxic/q28-q540.html)
- Reference Type:
- publication
- Title:
- No information
- Author:
- The European Parliament and the Council
- Year:
- 2 008
- Bibliographic source:
- Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures.
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: no guideline rreported
- Principles of method if other than guideline:
- The data was collected from a database only in order to classify the substance.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dichlobenil
- EC Number:
- 214-787-5
- EC Name:
- Dichlobenil
- Cas Number:
- 1194-65-6
- Molecular formula:
- C7H3Cl2N
- IUPAC Name:
- 2,6-dichlorobenzonitrile
Constituent 1
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 350 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Executive summary:
There is no data available on dermal toxicity testing with 3,4 -Dichlorobenzonitrile. In order to classify the substance (without any unnecessary animal testing) according to GHS relevant endpoint data for 2,6 -Dichlorobenzonitrile was read-acrossed to 3,4 -Dichlorobenzonitrile based on structural and physico chemical similarities (see rationale for reliability).
2,6 -Dichlorobenzonitrile is officially classified as acute Tox. 4 H312 ("Harmful in contact with skin"). Furthermore a entry in the Chemical Toxicity Database "RTECS number-DI3500000" refers a LD50 value of 1350 mg/kg, which also requires a classification as acute Tox. 4 H312.
Therefore and because of the same classification 2 -Chlorobenzonitrile in dermal toxicity, 3,4 -Dichlorobenzontrile was also classified as acute Tox. 4 H312.
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