Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 454-800-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- - Type: mixed population of aquatic microorganisms (activated sludge)
- Origin: aeration tank of a waste water plant treating predominantly domestic sewage (Wupper area water authority)
- Date of collection: 2004-08-17
- Pretreatment: none
- Concentration of inoculum: 30mg/L ss
Pretreatment of the test item
25 mg test item were weighed out on aluminium foil. This substance inclusive the aluminium foil was added to the test vessels to give a test concentration of 100 mg test item/L. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- Exposure conditions
- Test volume: 205 mL
- Test apparatus: Voith Sapromat
- Mixing: 1 magnetic stirrer per test vessel
- Incubation time: 28 d
- Incubation temperature: 22 ± 2°C - Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 8 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 16 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 22 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 28 d
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- 2-Chloro-5-chloromethylpyridine showed 0 % degradation after 28 days. Therefore 2-chloro-5-chloromethylpyridin has to be classified as "Not Readily Biodegradable".
- Executive summary:
A study was performed to assess the ready biodegradability of 2 -chloro-5 -chloromethylpyridine. The study was conducted in accordance with the Council Directive 92/69/EEC Method C.4-D "Manometric Respirometry Test". This test method is in all essential parts identical with OECD Guideline 301 F.
A suspension of 100 mg/L test item in a mineral medium is inoculated and incubated under aerobic conditions in the dark at a constant temperature (22 ± 2°C) for up to 28 days under aerobic conditions.
Allowance is made for the endogenous activity of the inoculum by running parallel blanks with inoculum but without test item. A reference compound (sodium benzoate) is run in parallel to check the operation of the procedures. Furthermore, a toxicity test (test item and reference compound mixed) is run in parallel. Because of the nature of biodegradation and of the mixed bacterial populations used as inocula, determinations are carried out at least in duplicate.
The consumption of oxygen is determined by measuring the quantity of oxygen (produced electrolytically) required to maintain constant gas volume in the respirometer flask. Evolved carbon dioxide is absorbed in a solution of potassium hydroxide. The amount of oxygen taken up by the test chemical (corrected for uptake by blank inoculum, run in parallel) is expressed as a percentage of theoretical oxygen demand (ThOD) or chemical oxygen demand (COD).
2-Chlor-5 -chloromethylpyridine showed 0 % degradation after 28 days. Therefore 2 -chloro-5 -chloromethylpyridine has to be classified as "Not Readily Biodegradable".
The reference compound showed 92 % degradation after 14 days.
Reference
Description of key information
A study was performed to assess the ready biodegradability of 2 -chloro-5 -chloromethylpyridine. The study was conducted in accordance with the Council Directive 92/69/EEC Method C.4-D "Manometric Respirometry Test". This test method is in all essential parts identical with OECD Guideline 301 F.
A suspension of 100 mg/L test item in a mineral medium is inoculated and incubated under aerobic conditions in the dark at a constant temperature (22 ± 2°C) for up to 28 days under aerobic conditions.
Allowance is made for the endogenous activity of the inoculum by running parallel blanks with inoculum but without test item. A reference compound (sodium benzoate) is run in parallel to check the operation of the procedures. Furthermore, a toxicity test (test item and reference compound mixed) is run in parallel. Because of the nature of biodegradation and of the mixed bacterial populations used as inocula, determinations are carried out at least in duplicate.
2-Chloro-5-chloromethylpyridine showed 0 % degradation after 28 days. Therefore 2-chloro-5-chloromethylpyridine has to be classified as "Not Readily Biodegradable".
The reference compound showed 92 % degradation after 14 days.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.