Registration Dossier
Registration Dossier
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EC number: 217-775-8 | CAS number: 1951-97-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Piperazine (CAS No 110-85-0) is the parent molecule from which piperazine, compound with phosphoric acid or piperazine phosphate (CAS No 1951-97-9) is synthesized. In medicine piperazine is used in the form of the hexahydrate or as the citrate, tartrate, phosphate (1951-97-9) or adipate. Thus, piperazine and piperazine phosphate can be considered as belonging to the same category.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Heterocyclic and miscellaneous nitrogen compounds.
- Author:
- Trochimowicz HJ, Kennedy GL and Krivanek CIH
- Year:
- 1 994
- Bibliographic source:
- In: Patty's Industrial Hygiene and Toxicology. Clayton GD and Clayton FE (eds). 4th Edition. John Wiley, New York. 2, 3315-3319
- Reference Type:
- other: study report
- Title:
- European Union Risk Assessment Report : Piperazine
- Author:
- European Chemicals Bureau
- Year:
- 2 005
- Bibliographic source:
- 3rd Priority List Volume: 56;Final Report, 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- standard acute method
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Piperazine
- EC Number:
- 203-808-3
- EC Name:
- Piperazine
- Cas Number:
- 110-85-0
- IUPAC Name:
- piperazine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal median lethal dose (LD50) of Piperazine in rabbit was found to be 4000 mg/kg/bw.Acute toxicity of Piperazine to rabbit by the dermal route indicates that Piperazine does not exhibits acute toxicity by the dermal route within the doses mentioned.
- Executive summary:
The acute dermal median lethal dose (LD50) of Piperazine in rabbit was found to be 4000 mg/kg/bw.Acute toxicity of Piperazine to rabbit by the dermal route indicates that Piperazine does not exhibits acute toxicity by the dermal route within the doses mentioned.
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