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EC number: 203-841-3 | CAS number: 111-17-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Only translated summary available, actual guideline not stated.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Only summary available, guideline not stated
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3,3'-thiodi(propionic acid)
- EC Number:
- 203-841-3
- EC Name:
- 3,3'-thiodi(propionic acid)
- Cas Number:
- 111-17-1
- Molecular formula:
- C6H10O4S
- IUPAC Name:
- 3-[(2-carboxyethyl)sulfanyl]propanoic acid
- Details on test material:
- - Name of test material (as cited in study report): Thiodipropionic acid (TDPA), 3,3’-thiodipropionic acid; bis(2-carboxyethyl) sulfide; ß,ß-thiodipropionic acid; 3,3’-thiobis(propanoic acid); 4-thiaheptanedioic acid; diethyl sulfide 2,2’-dicarboxylic acid; thiodihydracrylic acid
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories Japan, Inc.
- Age at study initiation: 5 weeks
- Weight at study initiation: males 133-150 g, females 111-126 g
- Fasting period before study: 18 h before until 3 h after dosing
- Housing: 5/cage
- Diet (e.g. ad libitum): solid feed for experimental animals (MF, Oriental Yeast Co. Ltd.), ad libitum
- Water (e.g. ad libitum): sterile-filtered and UV-radiated tap water, ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±2
- Humidity (%): 55±15
- Air changes (per hr): 12
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 200 mg/mL in 0.5 % CMC-Na aqueous solution (CMC-Na, Wako Pure Chemical Industries; Water for injection: Otsuka Pharmaceutical Factory)
- Amount of vehicle (if gavage): 10 mL/kg bw, calculated based on the bodyweight determined immediately prior to administration.
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg bw
DOSAGE PREPARATION (if unusual): Preparation of test substance suspension in CMC-solution 6 days in advance of administration. - Doses:
- 0, 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Survival, appearance, mobility, and other abnormalities on administration day immediately prior to administration and 0.5, 1, 3, and 6 hours after administration, then once a day thereafter for the rest of the observation period; bodyweight was measured immediately prior to administration (day 1) and then on days 2, 4, 8, 10, and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- F test was performed on bodyweights, in case of equal variance they were subjected to Student's t-test, in case of unequal variance they were subjected to Aspen-Welch's t-test. Significance level was 5 %.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: No effects were observed.
- Gross pathology:
- No effects were observed.
Any other information on results incl. tables
The test substance does not need to be classified according to the criteria of DSD or CLP.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity study equivalent to OECD TG 401, Crj: CD(SD) fasted rats (5/sex/dose) were orally administered with 0 (control) and 2000 mg/kg bw 3,3'-Thiobispropanoic acid in 0.5 % carboxymethyl cellulose by gavage. Animals were then observed for 14 d. No mortality occurred. No clinical signs were observed. There was no significant difference compared to controls. A low value for males in the treated group was found on day 8 due to food not being given to those animals from day 7 to day8. This observation was not attributed to test material administration. At necropsy, no macroscopic effects were observed. The LD50 was >2000 mg/kg bw.
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