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Diss Factsheets
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EC number: 204-068-4 | CAS number: 115-18-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was performed in accordance to the German national test guideline DIN 38412, part 11, October 1982
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: German standard DIN 38412, L15
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methylbut-3-en-2-ol
- EC Number:
- 204-068-4
- EC Name:
- 2-methylbut-3-en-2-ol
- Cas Number:
- 115-18-4
- Molecular formula:
- C5H10O
- IUPAC Name:
- 2-methylbut-3-en-2-ol
- Details on test material:
- - Name of test material (as cited in study report): 2-methylbuten-3-ol-2
- Analytical purity: > 99 %
- Lot/batch No.: 88/70
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The product was added to the test water without any pretreatment; subsequently the fish were placed in to the aquaria. A control (test water without test substance) was tested in parallel. No undissolved test substance was visible in the aquaria.
Test organisms
- Test organisms (species):
- Leuciscus idus
- Details on test organisms:
- TEST ORGANISM
- Common name: Golden orfe
- Length at study initiation (length definition, mean, range and SD): 7.7 cm (6.9-8.9 cm)
- Weight at study initiation (mean and range, SD): 4.3 g (2.8-6.6 g)
- Feeding during test: withdrawal of food 1 day before and during exposure
-Corpulence factor of the batch: 0.9
- Housing: Duration of housing: ca. 5 months Mortality during last 2 weeks of housing: ca. 1.0 % Medical treatment: twice with 0.05 mg/l malachite green chloride, once with 10 mg/l tetracycline hydrochloride Water temperature: 13 - 23°C
ACCLIMATION
- Acclimation period: 3 days
- Type and amount of food: growing feed (ad libitum);
- Health during acclimation (any mortality observed): 0.3 % Mortality
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Test temperature:
- 21 - 22°C
- pH:
- 7.3 to 7.8
- Dissolved oxygen:
- 7.2 to 8.8 mg/l
- Nominal and measured concentrations:
- Nominal test concentrations: control, 1000, 2150, 4640 and 10000 mg/l
- Details on test conditions:
- TEST SYSTEM
- Test vessel: all-glass aquaria (30 * 22 * 24 cm) filled
- Fill volume: 10 l
- Aeration: slight
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 4.3 g fish/l test water
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted freshwater according to DIN 38412, Part II, 1982) that was prepared from fully demineralised tap water by addition of 294.0 mg/l CaCl2*2 H2O, 123.3 mg/l MgSO4*7 H2O, 63.0 mg/l NaHCO3 and 5.5 mg/l KCl. The test water had a total hardness of 2.5 mmol/l, an acid capacity of 0.8 mmol/l and a pH of ca. 8.0.
- Intervals of water quality measurement: after 1, 24, 48, 72 and 96 hours of exposure
OTHER TEST CONDITIONS
- Photoperiod: 16:8 h (light:dark) - Reference substance (positive control):
- yes
- Remarks:
- chloroacetamide
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 2 200 - 4 600 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- 96 h NOEC 1000 mg/L (nominal) based on test material
96 h LC0 2150 mg/L (nominal) based on test material
96 h LC100 4600 mg/L (nominal) based on test material
Symptoms of intoxication (apathy, narcotic-like state, tumbling) could be observed at nominal 2150 mg/L. - Results with reference substance (positive control):
- The LC50 (48 h) of the positive control chloroacetamide was about 26 mg/l, which corresponds to the normal sensitivity of the fish.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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