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EC number: 226-603-0 | CAS number: 5435-64-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 1996 until April 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3,5,5-trimethylhexanal
- EC Number:
- 226-603-0
- EC Name:
- 3,5,5-trimethylhexanal
- Cas Number:
- 5435-64-3
- Molecular formula:
- C9H18O
- IUPAC Name:
- 3,5,5-trimethylhexanal
- Details on test material:
- Date of production: February/March 1996
Expiry date: March 1997
Properties: clear, colourless, liquid, visually homogenous
Stability: > 1 year
ph: not determinate
Purity: 91,2 mass % (gaschromatographic analysis)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Wistar (HsdCpb: WU/SPF) rat
200 - 300 g body weight; weight variation did not exceed +/- 20 % of the mean body weight
Housing: Makrolon type III cage, each cabe containing one rat
Acclimization: Animals were acclimatized for at least 5 days.
Room temperature: 22 +/- 3 ° C
Relative humidity: 30 - 70 %
Light: Arificial light, from 7.00 a.m. to 7.00 p.m.
Bedding: soft wood
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The undiluted liquid test substance (2.44 cm³/kg bodyweight) was applied by spreading it evenly over the prepared skin.
The treated area (approximately 50 x 50 mm) was then promplty covered with gauze which was held in place with a semiocclusive dressing
encircled firmly around the trunk. At the end of the 24 hours exposure period, the dressing was carefully removed and the treated area of
skin was cleaned with corn oil and absorbent paper. - Duration of exposure:
- 24 h
- Doses:
- single dermal application of 2.44 cm³/kg bodyweight
- No. of animals per sex per dose:
- 5 male, 5 female
- Control animals:
- no
- Details on study design:
- Approximately 24 h before treatment hair was removed from the dorsolumbar region of each rat with electric clippers exposing an area equivalent to approximately 10 % of the total body surface.
Initially two males and two females were given a single dermal application of the test substance at a dose level of 2000 mg/kg bodyweight. Since no mortalities occured within 24 h p.a., further three male and three female rats were treated in the same way.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- no indication of skin irritation up to the relevant limit dose level
- Mortality:
- There were no deaths following a single dermal application of TRIMETHYLHEXANAL at 2000 mg/kg bodyweight.
- Clinical signs:
- other: There were no signs of related systemic toxicity.
- Gross pathology:
- No macroscopic abnormalities were observed for animals killed on day 14.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The acute lethal dermal dose (LD50) to rats of TRIMETHYLHEXANAL was found to be greater than 2000 mg/kg bodyweight.
- Executive summary:
A study (limit-test) was performed to assess the acute dermal toxicity of TRIMETHYLHEXANAL to the rat. A group of ten rats (five male and five females) was given a single dermal application of the test substance at a dose level of 2000 mg/kg bodyweight. The treated area was covered for 24 h with gauze which was held in place by a semiocclusive dressing. All animals were killed and examined macroscopically on day 14, the end of the observation period.
There were not deaths and no signs of systemic reaction to treatment.
After removal of the dressings 24 h post applicationem (p.a.) until the end of the observation period no skin irritation were noted.
The male rats achieved satisfactory bodyweight gains throughout the study, whereas the female rats showed only minimal or no body weight gains. This effect is not considered to be substance related because variation of bodyweight in this age/bodyweight range in female rats is a physiological finding.
No abnormalities were recorded at the macroscopic examination on day 14.
The acute lethal dermal dose to male and female rats of TRIMETHYLHEXANAL was found to be > 2000 mg/kg.
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