Registration Dossier
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EC number: 921-836-0 | CAS number: 1190402-12-0
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects up to the limit of water solubility (< 1 mg/L) for Daphnia magna (OECD 211)
Key value for chemical safety assessment
Additional information
As no valid study is available for assessing the long-term toxicity to aquatic invertebrates of Mixed esters of fatty acid C16 and C16-C18-unsatd. with adipic acid and pentaerythritol, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the structurally related category member Fatty acids, C16-18 and C18-unsatd., mixed esters with adipic acid and trimethylolpropane (CAS No. 91001-61-5) was conducted. The read across is justified due to a) the structural similarity of the category members and b) similar physico-chemical properties resulting in a similar environmental fate and ecotoxicity profile. Further justification is given within the endpoint summary 6.1 and within the category justification section 13.
The chronic toxicity of Fatty acids, C16-18 and C18-unsatd., mixed esters with adipic acid and trimethylolpropane (CAS No. 91001-61-5) to aquatic invertebrates was tested in a guideline study following OECD 211 (Grell, 2013). Daphnia magna were exposed to the test substance in a semi-static test system. The water accommodated fraction (WAF) was used for the preparation of the test solutions. During the exposure period of 21 days the mortality and reproduction rate of the test animals was recorded. The substance affected neither the survival rate nor the reproduction rate of D. magna. Based on the loading rate a NOELR ≥ 110 mg/L was determined.
Thus, based on the above mentioned results, and due to the structural similarities and a consistent ecotoxicological/environmental fate profile of the substances, as are explained with in the overall endpoint summary in IUCLID chapter 6.1, it can be concluded that no chronic toxicity of Mixed esters of fatty acid C16 and C16-C18-unsatd. with adipic acid and pentaerythritol to aquatic invertebrates is expected.
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