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EC number: 607-654-1 | CAS number: 252285-60-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Not irritating to skin or eyes
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
An acute skin irritation study of the test item Triazin UV-Absorber was performed in New Zealand White rabbits. Parameters monitored during this study included mortality, body weight measurements and clinical observations. The irritation effects of the test item were evaluated according to the Draize method (OECD No.: 404, 2002). An amount of 0.5 g of the solid test item was applied neat to the skin of the experimental animals. The test item was applied as a single dose. Sufficient water to damp the material was used to ensure good contact with the skin and an adhesive clear plastic patch was applied. The trunk was wrapped in a semi-occlusive clear plastic film with medical tubing used to hold the patch in place. The untreated skin of each animal served as control. After 4 hours, the remaining test item was removed with water of body temperature. To assess skin irritation, animals were examined at 1, 24, 48 and 72 hours after the patch removal. Additional general examinations were performed daily. There was no mortality or systemic clinical change related to Triazin UV-Absorber administration. There was no effect of treatment on body weight.
During the observation at 1, 24, 48 and 72 hours after patch removal, there were no signs of skin irritation observed. The animals’ individual mean scores (considering readings at 24, 48 and 72 hours after patch removal) for erythema and oedema were 0.00 at all time points.
As no systemic or local clinical signs were observed at 72 hours after patch removal, the study was terminated after the 72-hour observation.
According to Directive 2001/59/EC and Regulation (EC) No 1272/2008, Triazin UV-Absorber does not require classification as a skin irritant. According to the UN Globally Harmonised System of Classification and Labelling of Chemicals, Triazin UV-Absorber does not require classification as a skin irritant.
An acute eye irritation study with Triazin UV-Absorber was performed in New Zealand White rabbits. The irritation effects of the test item were evaluated according to the Draize method (OECD No.: 405, 2002).
The test item was placed into the conjunctival sac of the left eye of each animal. The untreated right eye served as control. An amount of 100 mg of the solid test item was administered as a single dose. The eyes of the test animals were rinsed with 0.9% NaCl solution, one hour after application of the test item.
The eyes were examined at 1, 24, 48 and 72 hours after the application.
As there were no local or systemic clinical signs observed 72 hours after test item administration, the study was terminated after the 72-hour observation.
No abnormalities were detected in the control eyes during the entire study period.
Initial Pain reaction (score 1) was observed in all animals. All animals blinked several times in response to instillation of the test item.
One hour after the application, conjunctival redness (score 2) and discharge (score 2) was observed in all animals, and chemosis (score 1) was found in case of two animals.
At 24 hours after treatment, conjunctival redness (score 1) was observed in all animals.
At 48 hours after treatment, conjunctival redness (score 1) was found in one animal.
At 72 hours after treatment, there were no signs of eye irritation observed.
The general state and behaviour of animals were normal throughout the study period. There were no notable body weight changes during the study period.
The animal’s individual mean scores (considering readings at 24, 48 and 72 hours after the treatment) were as follows:
Animal Number |
Cornea Opacity |
Iris |
Conjunctivae |
||
Redness |
Chemosis |
Discharge |
|||
04079 |
0.00 |
0.00 |
0.33 |
0.00 |
0.00 |
00012 |
0.00 |
0.00 |
0.67 |
0.00 |
0.00 |
04086 |
0.00 |
0.00 |
0.33 |
0.00 |
0.00 |
The test item Triazin UV-Absorber, applied to the rabbit eye mucosa, caused significant conjunctival irritant effects at one hour which were reduced 24 hours after application. The effects were fully reversible within 72 hours.
According to Directive 2001/59/EC and Regulation (EC) No 1272/2008, Triazin UV-Absorber does not require classification as an eye irritant. According to the UN Globally Harmonised System of Classification and Labelling of Chemicals, Triazin UV-Absorber does not require classification as an eye irritant.
Justification for classification or non-classification
No classification necessary
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