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Diss Factsheets
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EC number: 257-288-8 | CAS number: 51566-62-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant non-guideline study, available as unpublished report, no restrictions, fully adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: the method that is described by Draize, J.H.
- Principles of method if other than guideline:
- According to Landsteiner/Draize (J.H. Draize, "Dermal toxicity", Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics (The Association of Food and Drug Officials of the United States, 1975), pp. 51-21. Twelve male Hartley guinea pigs were ten times intradermal exposed (concentration 0.1%) to 3,7-dimethyloct-6-enenitrile over a period of three weeks for induction. After a resting period of 2 weeks, the animals were challenged intradermally with 0.1% of the test substance.
- GLP compliance:
- yes
- Type of study:
- Draize test
- Justification for non-LLNA method:
- Data on skin sensitisation in guinea pigs is aldready available (Givaudan, 1980)
Test material
- Reference substance name:
- 3,7-dimethyloct-6-enenitrile
- EC Number:
- 257-288-8
- EC Name:
- 3,7-dimethyloct-6-enenitrile
- Cas Number:
- 51566-62-2
- Molecular formula:
- C10H17N
- IUPAC Name:
- 3,7-dimethyloct-6-enenitrile
- Details on test material:
- - Name of test material: Citronellal Nitril #04526, J79-261.
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 4-6 weeks.
- Weight at study initiation: 294-470 g.
- Housing: galvanized or stainless steel cages.
- Diet: growth and maintenance ration.
- Water: ad libitum.
- Acclimation period: 7 days.
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- physiological saline
- Concentration / amount:
- 0.1%
Challengeopen allclose all
- Route:
- intradermal
- Vehicle:
- physiological saline
- Concentration / amount:
- 0.1%
- No. of animals per dose:
- 12
- Details on study design:
- Twelve animals were prepared by close-clipping the mid-dorsal area of the trunk with a small animal clipper equipped with a #40 (surgical) head. The test site was an area 3 or 4 centimeters square located centrally in the clipped region.
Ten intradermal injections, using a 26 gauge hypodermic needle, were made at random in the test area over a period of 3 weeks. Each injection site was scored 24 hours following treatment, for diameter and height in millmeters and color (erythema), using the Draize skin scoring scale.
Two weeks after the last injection, a challenge injection was made, 0.05 mL of a freshly prepared batch of the test suspension. Observations were again recorded 24 hours for the parameters indicated above.
If the readings at the challenge were considerably higher than the average readings for the 10 induction injections, the test article was considered a sensitizer in guinea pigs. The proportional severity of the response determines the degree of sensitization.
Initial and terminal bodyweights were recorded. Animals surviving the full term of the study, as well as non-survivors, were subjected to gross necropsy, with all findings noted. - Challenge controls:
- No data.
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.05 mL
- No. with + reactions:
- 0
- Total no. in group:
- 12
- Clinical observations:
- No erythema or edema seen in any site following challenge.
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 0.05 mL. No with. + reactions: 0.0. Total no. in groups: 12.0. Clinical observations: No erythema or edema seen in any site following challenge..
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.