Registration Dossier
Registration Dossier
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EC number: 253-506-0 | CAS number: 37439-34-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 30 mg/kg bw/day
- Study duration:
- chronic
- Species:
- rat
Additional information
Increased liver and kidney weights were observed in both males and females at the highest dose level.
During study, administration of the test material was also associated with observations of staining and matting of the perineal hair, often in females of the highest dose level, less often in females of the middle dose, occasionally on males of the highest dose group; and frequently in females of the low dose level group. The cause of this perineal soiling and its toxicological significance is uncertain.
Body weights and weight gains of the male middle dose level group increased along with increased food consumption, perhaps because of increased palatability.
No adverse gross or histopathological findings, urinalysis, serum chemistry, or haematology changes were found that corresponded with the increased relative liver and kidney weights, the perineal staining and matting, or the increased food consumption, body weights and body weight gains.
The NOAEL for males and females was 30 mg/kgBW/day.
Justification for classification or non-classification
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