Trichloroacetyl chloride

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data is from computational model developed by USEPA

Justification for type of information:

Data is from computational model developed by USEPA

Qualifier:

according to guideline

Guideline:

other: Modeling database

Principles of method if other than guideline:

ECOSAR estimates log Kow values using the US EPA's KOWWIN Program for aquatic toxicity.Toxicity of a chemical was measured on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program based upon the octanol /water partition coefficient (Kow). Data from ECOSAR class,neutral organics was used.

The estimation methods in EPI Suite™ have been developed by government, academic, and private sector researchers over many years and represent some of the best techniques currently available. The intended application domain of EPI Suite is organic chemicals, and inorganic as well as organometallic chemicals generally can be considered outside the domain.

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Daphnia magna

Test type:

static

Water media type:

freshwater

Total exposure duration:

48 h

Reference substance (positive control):

no

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

769.89 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other: Estimated from Neutral Organics

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to aquatic invertebrates was predicted to be 769.89mg/l for test chemical in 48 hrs.
Based on this value it can be concluded that the substance was considered to be not toxic to aquatic environment and cannot be classified as per the criteria mentioned in CLP regulation.

Executive summary:

Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC50 value for short term toxicity to aquatic invertebrates was predicted.

On the basis of this program, the LC50 value for short term toxicity to aquatic invertebrates was predicted to be 769.89mg/l for test chemical in 48 hrs.

Based on this value it can be concluded that the substance was considered to be not toxic to aquatic environment and cannot be classified as per the criteria mentioned in CLP regulation.

Description of key information

The LC50 value for short term toxicity to aquatic invertebrates was predicted to be 769.89mg/l for test chemical in 48 hrs.

Based on this value it can be concluded that the substance was considered to be not toxic to aquatic environment and cannot be classified as per the criteria mentioned in CLP regulation.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

769.89 mg/L

Additional information

Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC50 value for short term toxicity to aquatic invertebrates was predicted.

On the basis of this program, the LC50 value for short term toxicity to aquatic invertebrates was predicted to be 769.89mg/l for test chemical in 48 hrs.

Based on this value it can be concluded that the substance was considered to be not toxic to aquatic environment and cannot be classified as per the criteria mentioned in CLP regulation.

 

Another test was conducted to determine the short-term toxicity of test chemical on daphnia magna. Thus, the EC50 value of test chemical after 60min was concluded to be 10mg/L.