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EC number: 610-962-9 | CAS number: 5311-05-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1998
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- other: Draft Renewal Assessment Report under Regulation (EC) 1107/2009
- Title:
- Draft Renewal Assessment Report under Regulation (EC) 1107/2009 - Tritosulfuron
- Year:
- 2 018
- Bibliographic source:
- Draft Renewal Assessment Report under Regulation (EC) 1107/2009
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.12 (Mutagenicity - In Vivo Mammalian Erythrocyte Micronucleus Test)
- Principles of method if other than guideline:
- According to the current OECD TG 474 (2014), intraperitoneal injection is generally not recommended. However, this way of exposure was used in the present study, since it was one of the recommended and routinely used administration routes in studies performed in accordance with the previous guideline OECD 474 (1997 and 1983). Nevertheless, since it was demonstrated that the test item was bioavailable, this deviation does not affect the validity of the study.
Additionally, at least 4000 PCE per animal should be scored for the incidence of micronucleated immature erythrocytes according to OECD TG 474 (2014). However, in the current study, only 2000 PCE per animal were scored, since this was required by the previous guideline OECD 474 (1997). Nevertheless, for the 48-hour exposure experiment, the required number of PCEs was scored (2 x 2000 PCE/animal) in order to verify the results obtained. - GLP compliance:
- yes
- Type of assay:
- mammalian bone marrow chromosome aberration test
Test material
- Reference substance name:
- 4-methoxy-6-(trifluoromethyl)-1,3,5-triazin-2-amine
- EC Number:
- 610-962-9
- Cas Number:
- 5311-05-7
- Molecular formula:
- C5H5F3N4O
- IUPAC Name:
- 4-methoxy-6-(trifluoromethyl)-1,3,5-triazin-2-amine
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
Results and discussion
Any other information on results incl. tables
Tables are attached separately
Applicant's summary and conclusion
- Conclusions:
- According to the results of the study, test item is not cytotoxic in mammalian germ cell.
- Executive summary:
Clastogenic/aneugenic activity of tritosulfuron metabolite test item was tested in vivo in NMRI mice. The maximum dose was selected based on severe toxicity, including mortality seen after intraperitoneal injection of 50, 100 and 500 mg/kg bw of the test item. After 24 hrs no increase in micronuclei formation was observed under study conditions. 48 hrs after administration of AMTT the increase in micronucleated PCE was reported compared to the concurrent control. However, the increase was within the HCD range for solvent control. The exposure of bone marrow is indirectly demonstrated by clinical signs observed in pretoxicity studies after single exposure to 12.5 and 25 mg/kg bw (reduction in spontaneous activity, eyelid closure, apathy abdominal position). Additionally, a study on kinetics in mice was performed, directly demonstrating the exposure of bone marrow to AMTT.
AMTT did not induce the formation of micronucleus in vivo under study conditions. The study was performed according to OECD 474 (1997) and principles of GLP. Despite deviations (intraperitoneal application, 2000 PCE scored per animals) the study is acceptable.
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