Registration Dossier
Registration Dossier
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EC number: 224-518-3 | CAS number: 4394-85-8
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
4-morpholinecarbaldehyde is with high probability acutely not harmful to algae.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 23 880 mg/L
- EC10 or NOEC for freshwater algae:
- 17 040 mg/L
Additional information
A non-GLP study on the toxicity to algae is
available. The study was conducted according to the German Industrial
Standard guideline DIN 38412, part 9 using Desmodesmus subspicatus
as test species. Based on the growth rate, the ErC50 (72h) was
determined to be 23880 mg/L, the 72h ErC10 was 17040 mg/L (BASF, 1990;
report no. 01/90/143). The test item concentrations were not
analytically verified but are assumed to be stable regarding the
substance's properties: low volatility, high water solubility, not
significantly bioaccumulative, adsorption not expected. The study meets
the validity criteria of the guideline with exception of the mean
coefficient of variation for section-by-section specific growth rates.
Therefore, results of the key study were supported with a calculation performed with QSAR Toolbox v4.4. The 72-h EC50 was determined to be 545 mg/L (BASF SE, 2021). Results were calculated with the read-across analysis method and the substance was within the applicability domain of the calculation model.
It can be concluded that 4-morpholinecarbaldehyde is with high probability acutely and chronically not harmful to algae.
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