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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 233-238-0 | CAS number: 10099-59-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitisation:
The potential for skin sensitisation of lanthanum trinitrate was evaluated using the local lymph node assay in the mouse (Henzell G, 2013).
according to OECD 429 guideline and EU method B.42. Following the results of preliminary study, three groups, each of four animals, were treated with the test item to dorsal ear surface as a suspension in dimethylformamide at concentrations of 10, 5 and 2.5% w/w. At concentrations of 5% and 10% w/w the stimulation indices were only slightly higher than the three-fold increase in 3HTdR incorporation compared to the control values (3.15 and 3.26 respectively). It was also observed that the preliminary screening animals showed excessive or elevated increases in ear thickness changes, indicating irritation potential. On this basis the test item could not be clearly classified as a sensitiser.
This study has been scored Klimisch 2 to reflect the ambiguity of the results (expert judgment) and the use of this study in a 'weight-of-evidence' approach according to the ECHA Practical guidance 2 'How to report weight of evidence'. Thus, the guideline indicates that a 'weight-of-evidence' approach should be used when several studies are available which give conflicting results.
In order to clarify the skin sensitisation potential of lanthanum trinitrate, a Guinea Pig Maximisation test (Török-Bathó M, 2013) was performed according to the OECD guideline 406, EU Method B.6 and EPA OPPTS 870.2600. The test item, formulated in saline solution, was applied to twenty animals per dose in the induction exposure phase (intra-dermal and dermal exposure). The dose for the intra-dermal injection was 0.01% (w/v) and 100% (w/v) for the dermal occlusive exposure. Fourteen days later, ten treated animals and five control animals were treated with the test item at a concentration of 100% (w/v). Remaining ten tested animals and five control animals were treated with 0.5 mL of the 50% dilution (safeguard dose). There were no dead animals and no local skin effects or adverse clinical responses, related to treatment, observed in either the test group or in the control group. There were no notable differences in bodyweights between the test animal group and the control group. The net response value represented an incidence rate of 0% after a challenge exposure at both 100 and 50% (w/v) lanthanum trinitrate. On the basis of the results of this study, the substance should be considered not to be a skin sensitiser.
Migrated from Short description of key information:
Skin sensitisation:
Lanthanum trinitrate was tested using the LLNA method (OECD 429 and EU Method B42 and in compliance with GLP). The substance was tested at 10%, 5% and 2.5% (w/w) concentrations. Based on the results of this K2 study (Henzell, 2013), the test result was considered inconclusive and then disregarded. Therefore, a Guinea pig maximisation test (GPMT) following OECD guideline 406, EU Method B.6 and US EPA OPPTS 870.2600, and in compliance with GLP, was performed. The result of this K1 test (Török-Bathó, 2013) concluded that this substance is clearly not a skin sensitiser.
Justification for selection of skin sensitisation endpoint:
Although this endpoint is covered by 'weight-of-evidence' approach, only the results of one of the two studies available are considered reliable.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the results of the guinea pig maximisation (Magnusson and Kligman method; OECD 406) study and according to the criteria of the DSD and CLP Regulation, lanthanum trinitrate should not be classified as skin sensitiser.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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