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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study with acceptable restrictions.

Data source

Reference
Reference Type:
other: inquiry data
Title:
Unnamed
Year:
2014

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V, B. 5
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
A mixture of: thiobis(4,1-phenylene)-S,S,S',S'-tetraphenyldisulfonium bishexafluorophosphate; diphenyl(4-phenylthiophenyl)sulfonium hexafluorophosphate
EC Number:
404-986-7
EC Name:
A mixture of: thiobis(4,1-phenylene)-S,S,S',S'-tetraphenyldisulfonium bishexafluorophosphate; diphenyl(4-phenylthiophenyl)sulfonium hexafluorophosphate
Cas Number:
74227-35-3
IUPAC Name:
(4-{[4-(diphenylsulfaniumyl)phenyl]sulfanyl}phenyl)diphenylsulfanium; diphenyl[4-(phenylsulfanyl)phenyl]sulfanium; tris(hexafluoro-λ⁵-phosphanuide)

Test animals / tissue source

Species:
other: White Russian Rabbit

Test system

Number of animals or in vitro replicates:
3 females

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: conj.redness
Basis:
animal #1
Score:
2.75
Remarks on result:
other: mean score
Irritation parameter:
other: conj.redness
Basis:
animal #2
Score:
2.5
Remarks on result:
other: mean score
Irritation parameter:
other: conj.redness
Basis:
animal #3
Score:
2.75
Remarks on result:
other: mean score
Irritation parameter:
other: conj.chemosis
Basis:
animal #1
Score:
2.25
Remarks on result:
other: mean score
Irritation parameter:
other: conj.chemosis
Basis:
animal #2
Score:
2.25
Remarks on result:
other: mean score
Irritation parameter:
other: conj.chemosis
Basis:
animal #3
Score:
2.25
Remarks on result:
other: mean score
Irritation parameter:
cornea opacity score
Basis:
animal #1
Score:
1.5
Remarks on result:
other: mean score
Irritation parameter:
cornea opacity score
Basis:
animal #2
Score:
1.2
Remarks on result:
other: mean score
Irritation parameter:
cornea opacity score
Basis:
animal #3
Score:
2
Remarks on result:
other: mean score
Irritation parameter:
iris score
Basis:
animal #1
Score:
2
Remarks on result:
other: mean score
Irritation parameter:
iris score
Basis:
animal #2
Score:
2
Remarks on result:
other: mean score
Irritation parameter:
iris score
Basis:
animal #3
Score:
2
Remarks on result:
other: mean score
Other effects:
Discharge and loss of hair around the eye was observed

Any other information on results incl. tables

Total score (Draize) : 57.

The animals were killed at day 9

Applicant's summary and conclusion