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Diss Factsheets
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EC number: 256-283-8 | CAS number: 46830-22-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Adequacy of study:
- other information
- Study period:
- 1992
- Rationale for reliability incl. deficiencies:
- other: Well documented report of a guideline study conducted to GLP.
Data source
Reference
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- - Name of test material (as cited in study report): ADAMQUAT BZ 80
- Physical state: liquid
- Analytical purity: 78.5% (in water)
- Impurities (identity and concentrations): Acrylic acid (0.54%), dimethylaminoethyacrylate (0.55%); EMHQ (0.0378%)
- Composition of test material, percentage of components: 100%
- Purity test date: 06/12/1991
- Lot/batch No.: op 611/613/615/616
- Expiration date of the lot/batch: 12/1992
- Stability under test conditions: stable
- Storage condition of test material: in the dark at room temperature
Constituent 1
Test animals
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elevage Cunicole de Val de Selle (80160 Prouzel, France)
- Age at study initiation: no data
- Weight at study initiation: 2.5 ± 0.1 kg
- Housing: individually housed in polystyrene cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 3°C
- Humidity (%): 50 ± 20% relative humidity
- Air changes (per hr): The air was non-recycled and filtered by absolute filters.
- Photoperiod (hrs dark / hrs light): 12 hours of light/12 hours of dark
IN-LIFE DATES: From: 16/01/1992 To: 25/01/1992
Test system
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 9 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: right flank
- % coverage:
- Type of wrap if used: semi-occlusive
REMOVAL OF TEST SUBSTANCE: no, since no residual was found
SCORING SYSTEM: Draize's score
Examination time points: 1h, 24 h, 48 h and 72 hours
Results and discussion
In vivo
Resultsopen allclose all
- Time point:
- other: 1 hour
- Score:
- 2
- Max. score:
- 4
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 1
- Max. score:
- 4
- Time point:
- other: 1 hour
- Score:
- 0.7
- Max. score:
- 4
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- Very slight and well-defined erythema was observed after application of the test substance in all animals. The mean scores were 0.0, 1.0 and 2.0 for each animal. A slight oedema was noted in one animal after one hour. Cutaneous reactions had reversed after 24 hours in one animal and from day 5 in the second animal. Very slight erythema and/or dryness of the skin persisted until day 9 in the last animal.
Any other information on results incl. tables
Rabbit Number | day 1 | day 2 | day 3 | day 4 | day 5 | day 6 | day 7 | day 8 |
1 hour | 24 hour | 48 hour | 72 hour | |||||
Erythema | ||||||||
01 | 2 | 0 | 0 | 0 | - | - | - | - |
02 | 2 | 2 | 2 | 2 | 1 | 1/S | 1/S | 1/S |
03 | 2 | 1 | 1 | 1 | 0 | - | - | - |
Oedema | ||||||||
01 | 0 | 0 | 0 | 0 | - | - | - | - |
02 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
03 | 2 | 0 | 0 | 0 | 0 | - | - | - |
S = dryness of the skin
- = Animals without reaction at the 72 hour scoring period were no longer observed
Applicant's summary and conclusion
- Conclusions:
- ADMAQUAT BZ 80 is not irritating to the skin of the rat.
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