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EC number: 235-183-8 | CAS number: 12124-97-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological information
Neurotoxicity
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Administrative data
Description of key information
The findings in a neutrotoxicological screening battery performed as part of the 90-day repeat oral dose study with ammoniumm bromide indicates that effects observed are probably reversible as evidenced in the four week recovery period at doses ≥225 mg/kg bw/day in both sexes.
Studies with sodium bromide give an NOAEL = 80 mg/kg bw/day (equivalent to 62.1 mg (Br-) /kg bw/day).
Key value for chemical safety assessment
Effect on neurotoxicity: via oral route
Link to relevant study records
- Endpoint:
- neurotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Principles of method if other than guideline:
- other
- GLP compliance:
- no
- Species:
- mouse
- Strain:
- other: C1300 mouse neuroblastoma cells, clone Neuro-2a
- Sex:
- not specified
- Route of administration:
- other: in vitro study
- Vehicle:
- water
- Duration of treatment / exposure:
- Exposure period: 2 day(s)
- Frequency of treatment:
- Continuous exposure
- Remarks:
- Doses / Concentrations:
0, 10-4, 10-5 and 10-6 M
Basis: - Control animals:
- yes, concurrent vehicle
- Details on study design:
- Type: other
Observation period: 2 day exposure period - Basis for effect level:
- other: see 'Remark'
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified
- Conclusions:
- A concentration of 10-6 M sodium bromide produces no noticeable effect light microscopically even after prolonged application (longer than 2 days). After a 2 day exposure to higher concentrations of sodium bromide and subsequent fixation of the mouse neuroblastoma cells, a pronounced increase in the length and branching of the processes or neurites is revealed. In addition there is an increase in the number of differentiated neuron-like mouse neuroblastoma cells treated with lower concentrations of sodium bromide. The length of processes, the number of branching and the cell number per area is significantly dependent on the concentration of the applied substances. The degree of branching per length of neuronal processes shows a slightly more pronounced effect when higher concentrations of sodium bromide are used.
- Endpoint:
- neurotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Principles of method if other than guideline:
- other
- GLP compliance:
- no
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male
- Route of administration:
- other: oral
- Vehicle:
- water
- Duration of treatment / exposure:
- Exposure period: 36 day(s)
- Frequency of treatment:
- Daily
- Remarks:
- Doses / Concentrations:
0, 400, 1200, 3600 and 10800 ppm
Basis: - No. of animals per sex per dose:
- 100
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Type: other
Observation period: 42 days pre-exposure, 36 days during exposure, 50 days post-exposure - Details on results:
- result is equivalent to: NOAEL = 310 ppm for the bromide ion
- Dose descriptor:
- NOAEL
- Effect level:
- 400 ppm
- Basis for effect level:
- other: based on behavioural activityTest
- Remarks on result:
- other:
- Dose descriptor:
- LOAEL
- Effect level:
- 1 200 ppm
- Basis for effect level:
- other: based on behavioural activityTest
- Remarks on result:
- other:
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