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EC number: 603-087-9 | CAS number: 125700-67-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08.02.2001 - 14.02.2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP-study, but the testarticle was not analyzed for identity, purity, composition or stability
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
- Principles of method if other than guideline:
- NIH Publication No. 99-4494
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- [(1H-1,2,3-benzotriazol-1-yloxy)(dimethylamino)methylidene]dimethylazanium; tetrafluoroboranuide
- Cas Number:
- 125700-67-6
- Molecular formula:
- C11H16BF4N5O
- IUPAC Name:
- [(1H-1,2,3-benzotriazol-1-yloxy)(dimethylamino)methylidene]dimethylazanium; tetrafluoroboranuide
- Details on test material:
- p.4 under identity of the tested chemical substances: the wrong "Benzotriazol-1-yl-tetramethyluronium tetrafluoroborate"-name is listed for the CAS number 125700-67-6
p.74: The correct name (1H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-, tetrafluoroborate(1-), 3-oxide (9CI) for CAS number 125700-67-6 is given.
however on
p. 84 The "uronium"-names (Benzotriazol-1-yl-tetramethyluronium tetrafluoroborate) are used in the attached safety data sheet
Lot Number: 217152
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Details on test animals and environmental conditions:
- total Number of animals:25,
age: 8-12 weeks,
weight: 18-25 g
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- DMSO
- Concentration / amount:
- 0.5%, 5%, 10%
Challenge
- Concentration / amount:
- 0.5%, 5%, 10%
- No. of animals per dose:
- 5
- Positive control substance(s):
- yes
- Remarks:
- DNCB
Study design: in vivo (LLNA)
- Vehicle:
- dimethyl sulphoxide
- Concentration:
- 0,1%
- No. of animals per dose:
- 5
- Details on study design:
- Mice were weighed on Days 1 and 6. Mice were treated on the dorsal surface of both ears, once per day on Days 1,2, and 3. A volume of 25 µl/ear was used. On day 6 the mice were injected i.v. with 20 µCi of ³H-thymidine in 250 µl of saline. Five hours later the mice were euthanized with CO2 and the draining auricular lymph nodes removed.
- Positive control substance(s):
- other: Dinitrochlorobenzene (DNCB)
- Statistics:
- f-distribution using SYSTAT(version 9.01, SYSTAT, Inc.). A Dunnetts tesdt was used to determine the degree of significance from control means.
Results and discussion
- Positive control results:
- stimulation index greater than 3 (5.91)
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: 10% - stimulation index 5.11, 5% - stimulation index 2.78, 0.5% - stimulation index 2.80, DNCB- stimulation index 5.91
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: 10% - 6338 (mean) 5% - 3454 (mean) 0.5% - 3476 (mean) DMSO- 1241 (mean) DNCB - 7334 (mean)
Any other information on results incl. tables
no significant changes were found with the body weights.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Conclusions:
- valid study for classification
- Executive summary:
- In a skin sensitization study with TBTU (0.5, 5, 10%) in DMSO, female mouse (CBA) were tested in LLNA (using the method of NIH Publication No. 99-4494). TBTU was found to have induced a hypersensitive response in mice, at a concentration of 10% as measured by the proliferation of lymphocytes in the draining lymph nodes. Consequently, TBTU is considered to be a potential sensitizer.
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