Registration Dossier
Registration Dossier
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EC number: 916-226-6 | CAS number: -
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
No DNEL can be derived for Katalysator WAZ 5596 B because not data from a repeated dose study are available. Maybe Katalysator WAZ 5596 B (CAS n° 65059-91-8) acts as a potential carcinogenic mixture, but the available data do not allow to reliable identify the threshold.
Local effects:
Due to the positive result of the in-vitro skin irritation test R38 (GHS: skin irritation category 2) is adequate.
In the HCE test Katalysator WAZ 5596 B was an ocular irritant under the conditions of this test method. In the following HET-CAM test Katalysator WAZ 5596 B was identified as "strong irritant" to the chorioallantoic membrane (Irritation Score (IS) = 10) under the conditions of this assay. Therefore a classification as R41 (GHS: eye irritation category Cat 1) is justified.
In a modified Local Lymph Node Assay (IMDS) Katalysator WAZ 5596-B was sensitising (R43 May cause sensitisation by skin contact) GHS: Skin Sens. 1A, H317: May cause an allergic skin reaction.
Therefore the high hazard band according the ECHA guidance document Part E – risk characterization applies and the risk management measures and operational conditions described there should be used
Systemic effects:
alpha-chlorotoluene is classified as Carc. Cat.2 (R45).
Therefore the high hazard band according the ECHA guidance document Part E – risk characterization applies and the risk management measures and operational conditions described there should be used
Overall the high hazard band according the ECHA guidance document Part E – risk characterization applies and the risk management measures and operational conditions described there should be used
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
Katalysator WAZ 5596-B has only industrial use. The general population is therefore not exposed to this material.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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