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EC number: 271-729-1 | CAS number: 68606-18-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (14 d) ≥ 1000 mg/kg dw for Eisenia fetida (OECD 207)
Key value for chemical safety assessment
Additional information
No experimental data evaluating the toxicity of Glycerides, mixed coco, decanoyl and octanoyl (CAS No. 68606-18-8) to soil macroorganisms are available. Therefore, toxicity data from analogue category members, propane-1,2,3-triyl trisheptanoate (CAS No. 620-67-7) and Glycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri- (CAS No. 91052-28-7), are used as read-across in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Glycerides, mixed coco, decanoyl and octanoyl is mainly a triglyceride formed by the combination of fatty acids of different C-chain lengths (C6 to C18 unsaturated) and glycerol. Propane-1,2,3-triyl trisheptanoate (CAS No. 620-67-7) is also a triglyceride with fatty acid chain length of C7. For Glycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri- (CAS No. 91052-28-7) the triester content is lower than for the other two substances (up to 15%), with a predominant monoester content. The lower degree of esterification might have an effect in the bioavailability to terrestrial organisms, due to a reduced size of the molecules, the potential to cross biological membranes is expected to increase. Therefore, Glycerides,C14-18 and C16-18 unsaturated, mono-, di- and tri- can be regarded as a worst-case read-across substance.The log Pow values of these three substances are > 4, indicating a high adsorption potential to soil particles. The water solubilities (< 0.05 mg/L) and aquatic toxicity profiles are also comparable (see Aquatic toxicity section). The two read-across substances cover the whole fatty acid C-chain range present in Glycerides, mixed coco, decanoyl and octanoyl. Therefore, they are considered to give a reliable indication of the toxicity of this substance to soil macroorganisms, and the read-across is justified.
Both tests were performed according to OECD 207, under GLP conditions (Muckle, 2012; Moser, 2012). In both studies, the test organism Eisenia fetida was exposed to the test substance for 14 days at a concentration of 1000 mg/kg dw (limit test). No effects on survival or biomass were reported during the exposure period, leading to NOEC values (14 d) ≥ 1000 mg/kg dw.
Glycerides, mixed coco, decanoyl and octanoyl is readily biodegradable. Therefore, rapid and ultimate degradation in the environment, including soil, can be expected. Chronic exposure of terrestrial organisms is thus very unlikely. Furthermore, this substance shows only low toxicity, if at all, to aquatic organisms. Due to the metabolization via enzymatic hydrolysis of the Glycerides category members, a relevant uptake and bioaccumulation in biota is not expected. Enzymatic breakdown will initially lead to the free fatty acid and glycerol. Glycerides are naturally stored by organisms as long-term energy reserves. Especially in periods in which the energy demand is high (reproduction, migration, etc.), glycerides are mobilized from the storage sites as source of fatty acids. Fatty acid catabolism is the most important energy source in many species, resulting in the release of acetyl CoA and NADH (throughβ-oxidation) and eventually, via the tricarboxylic cycle, the production of metabolic energy in the form of ATP. Please refer to IUCLID Section 5.3.1 for a detailed overview on bioaccumulation of the Glycerides category members.
Based on the results obtained for the structurally related category members (in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5) and the characteristics of Glycerides, mixed coco, decanoyl and octanoyl (CAS No. 68606-18-8), this substance is not expected to show toxicity to soil macroorganisms.
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