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Diss Factsheets
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EC number: 288-003-5 | CAS number: 85631-54-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
In one key study Butt et al. published the biotransformation of the 8:2 fluorotemoler acrylate in rainbow trout. The bioaccumulation and biotransformation of the 8:2 fluorotelomer acrylate was investigated in rainbow trout via dietary exposure. Very low levels of the 8:2 FTAc were detected in the internal tissues and feces, suggesting that the 8:2 FTAc was rapidly biotransformed in the gut or liver. Similarly, low concentrations of the 8:2 fluorotelomer alcohol (FTOH) were accumulated in the fish tissues. In a second publication Butt et al show showed that the 8:2 FTAc is rapidly biotransformed in the liver and stomach S9 fractions, with formation of the 8:2 FTOH observed within 30s to 1 min of incubation.
A supporting study with the read across substance 8:2 FTOH (main degradation product) published by MITI showed that the BCF of 8: FTOH is between 200 – 1100 (Test Concentration - 1st Concentration: 10 microg/L) or between 87 – 310 (Test Concentration - 2nd Concentration: 1 microg/L)
Brandsma: Dietary exposure of rainbow trout to PFOSA does not result in a significant accumulation of PFOSA (BMF of 0.023). The presence of PFOS showed that rainbow trout is able to metabolize PFOSA into PFOS. Half-lives of PFOSA and PFOS were 6.0 ± 0.4 and 16.9 ± 2.5 d, respectively. The fluorotelomer alcohols 8:2 FTOH and 10:2 FTOH are also rapidly metabolized to the fluorotelomer acids (8:2 FTCA, 10:2 FTCA) and the unsaturated acids (8:2 FTUCA, 10:2 FTUCA), respectively. Half-lives were 3.7 ± 0.4, 2.1 ± 0.5, 3.3, and 1.3 d for 10:2 FTCA, 10:2 FTUCA, 8:2 FTCA, and 8:2 FTUCA, respectively. Small quantities of PFOA and PFDA were also detected in rainbow trout exposed to 8:2 and 10:2 FTOH. The results indicate that the neutral precursors studied are rapidly transformed and eliminated by fish while their transformation products are generally more bioaccumulative.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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