Registration Dossier
Registration Dossier
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EC number: 274-713-2 | CAS number: 70643-20-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Effects on developmental toxicity
Description of key information
For the purpose of REACH registration, read across with the analogue substance 2-(2,4-diaminophenoxy)ethanol dihydrochloride appears appropriate. The test item, 2,4-diaminophenoxyethanol dihydrochloride, administered daily by gavage to pregnant female Sprague-Dawley rats from days 6 to 19 of gestation was well tolerated at 4 and 20 mg/kg bw/day. At 125 mg/kg bw/day, 11/24 females presented excessive salivation. The maternal body weight gain and food consumption were significantly lower throughout the dosing period. A slightly significantly lower fetal weight was observed at this dose-level, associated with a slightly higher number of fetuses with incomplete ossification of thoracic vertebra centrum and an increased incidence of short supernumerary 14th ribs. Under these experimental conditions, the NOAEL for maternal toxicity and embryofetal development are 20 mg/kg bw/day. A NOAEL of 25 mg/kg bw/day is calculated for 2,4 -diaminophenoxyethanol sulphate.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 25 mg/kg bw/day
- Species:
- rat
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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