Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-851-6 | CAS number: 383-63-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral: LD50 > 5000 mg/kg bw, 2 key studies (Reliability Kr.2, OECD 401)
Inhalation: no data , waiving
dermal: LD50 > 2011 mg/kg bw (Key study, Reliability Kr.2, OECD 402)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Good quality of whole database.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 011 mg/kg bw
- Quality of whole database:
- Good quality of whole database.
Additional information
Oral route:
Two different studies conducted on ethyl trifluoroacetate were considered as key studies. Both studies are not in compliance with GLP but present a good reliability (Kr. 2).
The first key study was conducted in 1983 (Monnot) similarly to the OECD guideline No. 401. Groups of male and female Sprague-Dawley rats were given by gavage a single oral dose of undiluted Ethyl trifluoroacetate (97.3 %). In the preliminary test, 3 doses were tested: 1011, 2511 and 5010 mg/kg bw. As no mortality occurred, the highest dose of 5010 mg/kg bw was chosen for the main test. A control group consisted in 2 males and 2 females, treated with deionized water, was also tested during the main test.. Two hours after the administration of the test item at 5010 mg/kg bw (main test), weariness was observed in all animals (males and females). This effect was observed during 24h in males and 72h in females. No mortality was observed neither in the treated group nor in the control group. Macroscopic examination of the main organs of the animals revealed no apparent abnormalities. Therefore the LD50 was determined to be higher than 5010 mg/kg bw.
The second key study was conducted in 1987 (Gardner) in accordance with the OECD guideline No. 401. Groups of male and female Sprague-Dawley rats were given by gavage a single oral dose of undiluted Ethyl trifluoroacetate (99.7 %). In the preliminary test, 2 doses were tested: 500 and 2000 mg/kg bw. As no mortality occurred, the highest recommended dose of 5000 mg/kg bw was chosen for the main test.Clinical signs and mortality were checked soon after dosing and then at frequent intervals for the remainder of day 1 (day of dosing). No death occurred in the main test at 5000 mg/kg bw. Piloerection, abnormal body carriage (hunched posture), abnormal gait (waddling) and lethargy were observed in all animals of both sex, treated with 5000 mg/kg bw, during the 4 hrs period after dosing. Pilo-erection alone persisted on day 2. There were no other clinical signs and recovery, as judged by external appearance and behaviour was apparently complete by day 3. No abnormalities were observed after necropsy. Therefore the LD50 was determined to be higher than 5000 mg/kg bw.
Under the test conditions, Ethyl Trifluoroacetate is not classified for acute oral toxicity according to the Annex I of the Regulation (EC) 1272/2008 (CLP) and the Annex VI of the Directive 67/548/EEC.
Dermal route:
A study was identified as a key study (Monnot, 1983). In this acute dermal toxicity study performed similarly to the OECD guideline No. 402 but not in compliance with the GLP, groups of male and female Sprague-Dawley rats were treated with a single dermal dose of undiluted Ethyl trifluoroacetate (97.3 %). In the preliminary test, 2 doses were tested: 1011 and 2011 mg/kg bw. As no mortality occurred, the highest dose of 2011 mg/kg bw was chosen for the main test. A group consisted in 2 males and 2 females, received no treatment, and served as control group during the main test. The test item was applied on the lateral dorsal area of rats and then the application site was covered with an occlusive dressing (silver foil and surgical tape). 24 hrs after the application of the test item, the dressing was removed and the application site was not washed. No mortalities occurred; neither clinical signs nor effects on body weight gain were observed. Macroscopic examination of the main organs of the animals revealed no apparent abnormalities.Therefore the LD50 was determined to be higher than 2011 mg/kg bw. Under the test conditions, Ethyl Trifluoroacetate is not classified for acute dermal toxicity according to the Annex I of the Regulation (EC) 1272/2008 (CLP) and the Annex VI of the Directive 67/548/EEC.
Justification for selection of acute toxicity – oral endpoint
Key study performed similarly to OECD guideline 401 but without GLP compliance.
Justification for selection of acute toxicity – dermal endpoint
Key study performed similarly to OECD guideline 402 but without GLP compliance.
Justification for classification or non-classification
Harmonized classification:
No harmonized classification is available for human health according to the Regulation (EC) No. 1272/2008 including the ATP2.
Self classification:
Oral route:
Based on the available data, the test item is:
- not classified according to the Regulation (EC) No. 1272/2008 as the LD50 is higher than 2000 mg/kg bw (and even > 5000 mg/kg bw)
- not classified according to the Directive 67/548/EEC as the LD50 is higher than 2000 mg/kg bw
Dermal route:
Based on the available data, the test item is:
- not classified according to the Regulation (EC) No. 1272/2008 as the LD50 is higher than 2000 mg/kg bw
- not classified according to the Directive 67/548/EEC as the LD50 is higher than 2000 mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.