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EC number: 234-858-4 | CAS number: 12037-47-7
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
ErC50 (72h) > 100 mg/L and NOEC (72h) ≥ 100 mg/L (OECD 201), RA
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity to algae of Silicon orthophosphate (CAS No. 12037-47-7) are available for this endpoint, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances and read-across, a read-across was conducted based on the products of dissociation. The read across is explained within the read across justification in section 13.
Silicon orthophosphate (CAS No. 12037-47-7) is readily soluble in water, dissociating into silicon and phosphate ions. Consequently, the chemical assessment is based on the products of dissociation. The substances which were chosen for the analogue read across approach yield the same ions as the target substance (either ionic silicon or ionic orthophosphate) when dissolved in water. Data from phosphoric acid, potassium salt (2:3), dihydrate (CAS No. 6922-99-4) are used to cover the toxicity to algae of the phosphate moiety of the substance. Data from sodium aluminum silicate (CAS No. 1344 -00 -9) are used to cover the silicon moiety of the substance.
Algal toxicity of phosphoric acid, potassium salt (2:3), dihydrate was investigated (CAS No. 6922-99-4) in a 72 h limit test according to OECD 201 and GLP, including analytics (Vyrenhoef and Mullee, 2010). At a nominal test concentration of 100 mg/L, no inhibition of growth rate and no abnormalities of the cells could be observed. Analysis of the test preparations at 0 and 72 h showed measured test concentrations to range from 107% to 113% of nominal values. Therefore, an ErC50 (72h) > 100 mg/L and a NOErC ≥ 100 mg/L based on nominal concentrations were assumed.
Sodium aluminum silicate (CAS No. 1344-00-9) was tested in a 72 h study according to OECD 201 and GLP, without analytical verification of the test substance concentrations (Lebertz, 1998). Algae were exposed to filtered test solutions at nominal 96, 1008 and 10,000 mg/L. As no inhibition of algal growth and no abnormalities occurred, an ErL50 (72h) > 10,000 mg/L (nominal) was stated.
Therefore, based on the read across approach an ErC50 (72h) > 100 mg/L and NOEC (72h) ≥ 100 mg/L can be assumed for silicon orthophosphate.
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