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EC number: 257-077-0 | CAS number: 51240-95-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06 May 1986 - 21 May 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,1,3,3-tetramethylbutyl peroxyneodecanoate
- EC Number:
- 257-077-0
- EC Name:
- 1,1,3,3-tetramethylbutyl peroxyneodecanoate
- Cas Number:
- 51240-95-0
- Molecular formula:
- C18H36O3
- IUPAC Name:
- 2,4,4-trimethylpentan-2-yl 2,2,3,5-tetramethylhexaneperoxoate; 2,4,4-trimethylpentan-2-yl 2,2-diethylhexaneperoxoate; 2,4,4-trimethylpentan-2-yl 2,2-dimethyloctaneperoxoate; 2,4,4-trimethylpentan-2-yl 2,4-dimethyl-2-(propan-2-yl)pentaneperoxoate; 2,4,4-trimethylpentan-2-yl 2-ethyl-2,5-dimethylhexaneperoxoate
- Details on test material:
- - Chemical name: Neodecane peroxoic acid 1,1,3,3-tetramethyl butyl ester
- Appearance: Colouless clear liquid
- CAS-reg. no.: 51240-95-0
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: The Broekman Institute, Someren, The Netherlands.
- Age at study initiation: animal 260: 09-12-1985, 8 to 10 weeks old; animal 295: 12-03-1986, 8 to 10 weeks old; animal 450: 10-04-1986, 12 to 14 weeks old.
- Weight at study initiation: see above
- Housing: They were individually housed in plastic cages with perforated floors.
- Diet (e.g. ad libitum):ad libitum, standard laboratory animal diet (100 g per day), obtained from Hope Farms, Woerden (LK-01, pellet diameter 4 mm)
- Water (e.g. ad libitum):ad libitum
- Acclimation period:7-days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-22
- Humidity (%): 60-85
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: 06 May 1986 - 21 May 1986
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipping
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: contralateral flank
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): as such
During dose administration the test substance was kept on ice. - Duration of treatment / exposure:
- 4 hours
- Observation period:
- The exposed skin areas were examined for signs of erythema and oedema and the responses were scored at 60 minutes, and approximately 24, 48 and 72 hours, and 7 and 14 days after removal of the patch. For reference the control site on the contralateral flank was used. In order to facilitate the scoring, the skin area concerned of animals no. 450 was shaved again before the observations on day 14.
- Number of animals:
- 3 females
- Details on study design:
- TEST SITE
- Area of exposure: 6cm2
- % coverage: -
- Type of wrap if used: 6 cm2 gauze patch, which was attached with a drop of petrolatum to al uminium foil and mounted on permeable tape (Micropore, 3M, St. Paul, USA). This was applied to the right flank of each animal, the left flank being covered with the same dressing without testsubstance. Finally, the animals were wrapped in flexible bandage (Coban, 3M, St. Paul, USA).
REMOVAL OF TEST SUBSTANCE
- Washing (if done): tissue moistened with tap-water.
- Time after start of exposure: 4 hours
SCORING SYSTEM:
Scoring system Erythema and oedema
Erythema and eschar formation
No erythema 0
Very slight erythema (barely perceptible) 1
Well defined erythema 2
Moderate to severe erythema 3
Severe erythema (beet redness) to slight eschar formation (injuries in depth) 4
Oedema formation
No oedema 0
Very slight edema(barely perceptible) 1
Slight edema(edges of the area well defined by definite raising) 2
Moderate edema(raised approximately 1mm) 3
Severe edema( raised more than 1 mm and extending beyond the area of exposure) 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- all animals
- Time point:
- 24/48/72 h
- Score:
- 1.88
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- all animals
- Time point:
- 24/48/72 h
- Score:
- 0.44
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritant / corrosive response data:
- The skin of the animals showed very slight oedema, persisting for 24 to 48 hours, and moderate erythema. In one of the animals (no. 260) the redness was still present 7 days after dosing, while the skin of animal 295 showed well-defined erythema for 3 days. In case of animal 450 the adverse skin effects had disappeared on day 3. Scale formation was observed on the treated skin area of all animals from day 7 onwards. Signs of systemic intoxication were not observed in any of the rabbits.
- Other effects:
- None
Any other information on results incl. tables
no. |
Effect |
Hour |
Days after application |
Mean score erythema 24/48/72 h |
Mean score oedema 24/48/72 h |
||||
1 |
1 |
2 |
3 |
7 |
14 |
|
|
||
1 |
Erythema/ eschar Oedema |
2
2 |
2
1 |
2
1 |
2
0 |
2
0 |
0
0 |
2 |
0.67 |
2 |
Erythema/ eschar Oedema |
1
1 |
3
1 |
2
0 |
2
0 |
0
0 |
0
0 |
2.33 |
0.33 |
3 |
Erythema/ eschar Oedema |
1
1 |
3
1 |
1
0 |
0
0 |
0
0 |
0
0 |
1.33 |
0.33 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The mean value for eshar/erythema is =>1.5 and =< 2.3 for 2 out of 3 animals. The oedema score is < 1.5. Although the scoring does not warrant classification, the substance is classified as irritant because of the scaling observed from day 7 onwards.
- Executive summary:
A sample of the test substance was tested in the rabbit primary skin irritation/corrosion test to determine its possible irritating or corrosive effects.
The flank skin of 3 female rabbits was exposed to 0.5 ml of the test substance for 4 hours using semi-occlusive dressing. This resulted in very slight, temporary oedema, and moderate erythema, which persisted for seven days in one animal and for two to three days in the other animals. The treated skin area of all animals showed scale formation from day 7 onwards. Based on the scores that were obtained the substance is considered a mild skin irritant.
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