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Diss Factsheets
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EC number: 619-566-0 | CAS number: 848301-65-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- one-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Although the tests on the substance 'Light Alkylate Naphtha' indicated that the test material may not be a reproductive toxin (IUCLID data have not undergone any evaluation by the European Commision), the substance 'Naphtha (Fischer-Tropsch), light, C4-10, branched and linear' is stated to contain up to 6% n-hexane, which is classified in the EU as 'Toxic to Reproduction Category 3 (R62)' (concentrations >= 5%). Therefore 'Naphtha (Fischer-Tropsch), light, C4-10, branched and linear' should be also classified as 'Toxic to Reproduction Category 3 (R62)'.
Data source
Reference
- Reference Type:
- other: IUCLID Dataset
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 421 (Reproduction / Developmental Toxicity Screening Test)
- Version / remarks:
- (modified)
- Deviations:
- not specified
- Principles of method if other than guideline:
- no data
- GLP compliance:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- no data
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- - exposure: 6 hours per day
- duration: 8 weeks (males)
9 weeks (females) - Frequency of treatment:
- 7 days per week
- Details on study schedule:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 5.1, 12.5, 24,7 mg/l
Basis:
no data
- No. of animals per sex per dose:
- no data
- Control animals:
- yes
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Effect level:
- 24.7 mg/L air
- Sex:
- male/female
- Basis for effect level:
- other: no effect on parental food consumption, body weight or fertility up to and including 24.7 mg/l dose level
Results: F1 generation
Effect levels (F1)
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 24.7 mg/L air
- Sex:
- male/female
- Basis for effect level:
- other: no data
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- During the study of 'Light Alkylate Naphtha' (CAS No. 64741-66-8] no clinical signs indicative of systematic toxicity were observed. Inhalation exposure had no effect on parental food consumption, body weight or fertility, up to and including the 24.7 mg/l dose level. Evaluation of the parental reproductive organs (ovaries, testes and epididymides) did not reveal any weight or microscopic changes attributable to exposure. There were no differences in the mean number of corpora lutea, implantation sites and live pups per litter. Pups born from treated mothers showed comparable birth weights and weight gains. On postnatal day 4, all groups had a viability index >97%. Finally no gross anomalies were observed in pups.
Although the tests on 'Light Alkylate Naphtha' indicated that the test material may not be a reproductive toxin, the substance 'Naphtha (Fischer-Tropsch), light, C4-10, branched and linear' is stated to contain up to 6% n-hexane, which is classified in the EU as 'Toxic to Reproduction Category 3 (R62)' (concentrations >= 5%). Therefore 'Naphtha (Fischer-Tropsch), light, C4-10, branched and linear' should be also classified as 'Toxic to Reproduction Category 3 (R62)'.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.