4,4'-methylenebis(2,6-xylidine)

Ecotoxicological Summary

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:

PNEC aqua (freshwater)

PNEC value:

0.001 mg/L

Assessment factor:

1 000

Extrapolation method:

assessment factor

PNEC freshwater (intermittent releases):

0.005 mg/L

Marine water

Hazard assessment conclusion:

PNEC aqua (marine water)

PNEC value:

0 mg/L

Assessment factor:

10 000

Extrapolation method:

assessment factor

STP

Hazard assessment conclusion:

PNEC STP

PNEC value:

100 mg/L

Assessment factor:

10

Extrapolation method:

assessment factor

Sediment (freshwater)

Hazard assessment conclusion:

PNEC sediment (freshwater)

PNEC value:

0.813 mg/kg sediment dw

Extrapolation method:

equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:

PNEC sediment (marine water)

PNEC value:

0.081 mg/kg sediment dw

Extrapolation method:

equilibrium partitioning method

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:

PNEC soil

PNEC value:

0.162 mg/kg soil dw

Extrapolation method:

equilibrium partitioning method

Conclusion on classification

No experimental data are available for 4,4'-methylenebis(2,6-xylidine) (CAS 4073 -98 -7). For the purpose of classification, read aross is made to the structurally similar substances 4,4'-methylenebis(2-methylaniline) (CAS 838 -88 -0) and N,N,N',N'-tetramethyl-4,4'-methylendianiline (CAS 101 -61 -1).

LC/EC50 values for CAS 838 -88 -0 and CAS 101 -61 -1 are available from four species representing three trophic levels (fish, invertebrates and algae). Results for fish indicate that acute effects are not to be expected at the maximum water solubility. The most sensitive species are invertebrates (48 -h EC50 = 0.531 mg/L). Chronic toxicity data are only available for algae. Based on results for the 72 -h test period, the NOErC is < 0.02 mg/L and the ErC10 is 0.26 mg/L.

 

Official classification regarding environmental hazards:

Aquatic compartment

1) 4,4'-methylenebis(2,6 -xylidine) (CAS 4073 -98 -7)

In accordance with Regulation (EC) No 1272/2008 Annex VI Table 3.1 or Table 3.2: no data found

2) 4,4'-methylenebis(2-methylaniline) (CAS 838 -88 -0)

In accordance with Regulation (EC) 1272/2008 Annex VI Table 3.1: Aquatic acute 1; Aquatic chronic 1

In accordance with Regulation (EC) 1272/2008 Annex VI Table 3.2: N; R50-53

3) N,N,N',N'-tetramethyl-4,4'-methylendianiline (CAS 101 -61 -1)

In accordance with Regulation (EC) 1272/2008 Annex VI Table 3.1: Aquatic acute 1; Aquatic chronic 1

In accordance with Regulation (EC) 1272/2008 Annex VI Table 3.2: N; R50 -53

Self-classification

 

Aquatic compartment

Following DSD/DPD, the substance is classified as dangerous for the environment (symbol 'N', R50/53) since the acute toxicity to aquatic organisms (LC/EC50) is ≤ 1 mg/L, the substance is not readily biodegradable and the determined log Pow is ≥ 3 (no experimentally determined BCF).

 

Following GHS, the substance is classified as hazardous to the aquatic environment into the acute category 1, since the lowest acute effect value is < 1 mg/L.

Chronic data are available only for algae (CAS 838 -88 -0, NOEC < 0.1 mg/L), therefore classification is based on the available chronic and acute toxicity data. The chronic data indicate that the test substance is to be classified as hazardous to the aquatic environment. The lowest acute effect value is < 1 mg/L and the test substance is not readily biodegradable and its log Pow is > 4. Therefore, the substance is classified as hazardous to the aquatic environment into the chronic category 1. The M-factor is 1 for both acute and chronic toxicity.

Atmospheric compartment

The test substance is not listed in Annex 1 of Regulation (EC) 2037/2000 on substances that deplete the ozone layer.

The test substance does not belong to the greenhouse gases listed in P Forster, PV Pamaswamy et al. Changes in Atmospheric Constituents and Radiative Forcing. In: Climate Change 2007: The Physical Basis. Contribution of Working Goup 1 to the Fourth Assessment Report of the Intergovernmental Panel on climate Change.