Registration Dossier
Registration Dossier
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EC number: 208-782-7 | CAS number: 541-47-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Adequacy of study:
- other information
- Study period:
- 1997-01-17-1997-01-31
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No detailed information (number of animals,strain, dose)
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- other: Method B4 of Commission Directive 92/69/EEC
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-methylcrotonic acid
- EC Number:
- 208-782-7
- EC Name:
- 3-methylcrotonic acid
- Cas Number:
- 541-47-9
- Molecular formula:
- C5H8O2
- IUPAC Name:
- 3-methylbut-2-enoic acid
- Details on test material:
- Storage: at approximately 4°C
Constituent 1
Test animals
- Species:
- rabbit
- Details on test animals or test system and environmental conditions:
- Semi-occlusive application on the intact rabbit skin.
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- No concentration information documented
- Duration of treatment / exposure:
- 3 minute , 1 and 4-hours application.
- Observation period:
- 72 hour observation
- Number of animals:
- No data
- Details on study design:
- The study was performed to assess the irritancy potential of the test material following single 3 minutes, 1 and 4 hour, semi-occluded application. The test system was chosen, because the rabbit has been shown to be a suitable model.
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material was classified as corrosive to rabbit skin.
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